• Publications
  • Influence
Membrane protein folding and stability: physical principles.
  • S. White, W. Wimley
  • Chemistry, Medicine
    Annual review of biophysics and biomolecular…
  • 1999
TLDR
A coherent thermodynamic formalism for determining and describing the energetics of peptide-bilayer interactions and a review of the properties of the environment of membrane proteins--the bilayer milieu are reviewed.
Experimentally determined hydrophobicity scale for proteins at membrane interfaces
TLDR
A complete interfacial hydrophobicity scale that includes the contribution of the peptide bond was determined from the partitioning of two series of small model peptides into the interfaces of neutral (zwitterionic) phospholipid membranes.
Recognition of transmembrane helices by the endoplasmic reticulum translocon
TLDR
The results indicate that direct protein–lipid interactions are critical during translocon-mediated membrane insertion, and the basic features of this code are determined, including a ‘biological’ hydrophobicity scale.
Molecular code for transmembrane-helix recognition by the Sec61 translocon
TLDR
Using in vitro translation of a model protein in the presence of dog pancreas rough microsomes to analyse a large number of systematically designed hydrophobic segments, a quantitative analysis of the position-dependent contribution of all 20 amino acids to membrane insertion efficiency is presented.
A comprehensive classification system for lipids11 The evaluation of this manuscript was handled by the former Editor-in-Chief Trudy Forte. Published, JLR Papers in Press, February 16, 2005. DOI
TLDR
A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
Solvation energies of amino acid side chains and backbone in a family of host-guest pentapeptides.
TLDR
The very large peptide bond ASP, -96 +/- 6 cal/mol/A2, profoundly affects the results of computational comparisons of protein stability which use ASPs derived from octanol-water partitioning data.
Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structure.
TLDR
The "dynamic bilayer thickness" which describes the minimum effective thickness of the hydrocarbon permeability barrier in terms of the thermal motion of the water is discussed, and the steric interactions between headgroups of apposed bilayers are clearly revealed.
MPEx: A tool for exploring membrane proteins
TLDR
Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy‐plot software tool for analyzing membrane protein sequences that facilitates the characterization and identification of favorable protein transmembrane regions using experiment‐based physical and biological hydrophobicity scales.
How to measure and analyze tryptophan fluorescence in membranes properly, and why bother?
TLDR
It is shown that Trp spectra can be obtained in the presence of up to 6 mM LUV that are virtually identical to spectra obtained in buffer alone, which obviates the use of SUV.
A comprehensive classification system for lipids.
TLDR
A structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases.
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