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Oral Absorption of Peptides Through the Cobalamin (Vitamin B12) Pathway in the Rat Intestine
AbstractPurpose. This study was aimed at examining the extent and mechanismof uptake of cobalamin (Cbl)-conjugated peptides in vitro and in vivo. Methods. To enable acquisition of quantitativeExpand
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Feasibility of a liquid-phase microextraction sample clean-up and liquid chromatographic/mass spectrometric screening method for selected anabolic steroid glucuronides in biological samples.
Anabolic androgenic steroids (AAS) are metabolized extensively in the human body, resulting mainly in the formation of glucuronide conjugates. Current detection methods for AAS are based on gasExpand
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Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin.
As a prelude to the development of orally active erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF), conjugates have been formed between these molecules and vitamin B12. DuringExpand
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Vitamin B12-mediated uptake of erythropoietin and granulocyte colony stimulating factor in vitro and in vivo
Abstract Proteins are normally very poorly absorbed from the intestine as the intestinal epithelial cells act as a barrier to the uptake of all but the smallest of molecules. We have used the naturalExpand
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Synthesis of LHRH antagonists suitable for oral administration via the vitamin B12 uptake system.
Conjugates have been synthesized between vitamin B12 and two lysyl derivatives of the LHRH antagonist, ANTIDE. Lys6-ANTIDE and Lys8-ANTIDE were both found to have similar activities to the nativeExpand
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Oral delivery systems microparticle.
DESCRIBED COMPLEX AND ORAL COMPOSITIONS FOR THE DISTRIBUTION OF A SUBSTANCE OR SUBSTANCES IN LYMPHATIC DRAINAGE SYSTEM OR CIRCULATORIO a host. The complexes of the invention comprise a microparticleExpand
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Oral Absorption of Peptides
absorption from the intestine (10,11). For the vast majority of Received March 7, 2000; accepted April 11, 2000 larger polypeptides, oral absorption is limited by their susceptiPurpose. This studyExpand
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Rearrangement of suitably constituted aryl, alkyl, or vinyl radicals by acyl or cyano group migration
Transposition des bromo-2 benzenepropionates d'ethyle, substitues en α par un groupe acetyl ou cyano, en acetyl-2 et cyano-2 benzenepropionate d'ethyle. Synthese d'oxo-3 cyclanecarboxylates d'alkyleExpand
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Simultaneous determination of various cardiac glycosides by liquid chromatography-hybrid mass spectrometry for the purity assessment of the therapeutic monitored drug digoxin.
A high performance liquid chromatography-hybrid tandem mass spectrometry (LC-MS(n)) method utilising electrospray ionisation has been developed and implemented for the simultaneous determination ofExpand
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Cyano or acyl group migration by consecutive homolytic addition and β-fission
Suitably constituted aryl and alkyl radicals readily rearrange by 1,2- or 1,4-acyl or cyano migration.
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