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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.
Microarray analysis of RNA from hESCs maintained under either 4% or 20% O(2) conditions indicated that genes associated with pluripotency, including OCT4, SOX2, and NANOG were generally unaffected, while some genes controlled by these transcription factors showed lowered expression, while a few genes implicated in lineage specification were up-regulated.
Effects of fgf2 and oxygen in the bmp4-driven differentiation of trophoblast from human embryonic stem cells.
Inositol phosphate stimulation by LH requires the entire α Asn56 oligosaccharide
Human embryonic stem cells as models for trophoblast differentiation.
Microenvironmental regulation of ovarian cancer metastasis.
Unlike most carcinomas that initially de-differentiate during neoplastic progression, ovarian carcinomas undergo a mesenchymal-epithelial transition and acquire a more differentiated epithelial phenotype resulting in significant morphologic heterogeneity as tumors acquire increasingly complex differentiation reminiscent of the highly specialized epithelia of Mullerian duct origin.
Inositol phosphate stimulation by LH requires the entire alpha Asn56 oligosaccharide.
Purified oLHalpha Asn(56) oligosaccharides inhibited FSH-stimulated steroidogenesis in rat granulosa cell cultures indicating a direct role for carbohydrate in FSH action.
Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.
It is demonstrated that PGF2alpha activates the Raf/MEK1/p42/44mapk signaling cascade in bovine luteal cells and that the actions of P GF2alpha are mimicked by the PKC activator PMA.
Putative role of the phosphatidylinositol 3-kinase — Akt signaling pathway in the survival of granulosa cells
The data suggest that IGF-I-induced phosphorylation of Akt is mediated through PI 3-kinase and that inactivation of this pathway results in granulosa cell apoptosis and it is concluded that the P1 3-Kinase/Akt signaling serves as a functional survival pathway in the ovary.
Activates Wnt / β-catenin Signaling in Ovarian Cancer Lysophosphatidic Acid Initiates Epithelial To Mesenchymal Transition and Induces Beta-Catenin-Mediated Transcription In Epithelial Ovarian…
The results suggest that LPA initiates EMT in ovarian tumors through β1-integrin-dependent activation of Wnt/βcatenin signaling, providing a novel mechanism for mutation-independent activation of this pathway in EOC progression.
Prostaglandin F2α Stimulates the Raf/MEK1/Mitogen-Activated Protein Kinase Signaling Cascade in Bovine Luteal Cells.
In vitro protein kinase assays demonstrated that activation of Raf-1 and B-Raf resulted in the phosphorylation and activation of MAPK kinase (MEK1), which led to transcriptional activation in response to PGF2α.