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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.
To realize the full potential of human embryonic stem cells (hESCs), it is important to develop culture conditions that maintain hESCs in a pluripotent, undifferentiated state. A low O(2) atmosphereExpand
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Effects of fgf2 and oxygen in the bmp4-driven differentiation of trophoblast from human embryonic stem cells.
Human embryonic stem cells (hESC) differentiate into trophoblast when treated with BMP4. Here we studied the effects of either low (4 % O(2), L) or atmospheric O(2) (20% O(2), A) in the presence andExpand
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Human embryonic stem cells as models for trophoblast differentiation.
Trophectoderm is specified from pluripotent blastomeres at some time prior to blastocyst formation. Proliferating cytotrophoblast derived from trophectoderm is the forerunner of the entireExpand
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Microenvironmental regulation of ovarian cancer metastasis.
Tumors arising from the ovarian surface epithelium (OSE) account for the vast majority of ovarian malignancies; however, the etiology of epithelial ovarian cancer (EOC) remains poorly understood, andExpand
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Inositol phosphate stimulation by LH requires the entire alpha Asn56 oligosaccharide.
Lentil lectin-bound, fucose-enriched hTSH was reported to stimulate both cAMP and inositol phosphate (IP) intracellular signalling pathways, whereas fucose-depleted hTSH stimulated only the cAMPExpand
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Putative role of the phosphatidylinositol 3-kinase — Akt signaling pathway in the survival of granulosa cells
Insulin-like growth factor-1 (IGF-1) is an important differentiation and survival factor for granulosa cells. The purpose of this study was to test the hypothesis that IGF-1 promotes survival ofExpand
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Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma*
Background: Aberrant activation of Wnt/β-catenin signaling is found in ovarian cancer, even when mutations are absent. Results: The bioactive lipid lysophosphatidic acid induces β1-integrinExpand
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Activates Wnt / β-catenin Signaling in Ovarian Cancer Lysophosphatidic Acid Initiates Epithelial To Mesenchymal Transition and Induces Beta-Catenin-Mediated Transcription In Epithelial Ovarian
During tumor progression, epithelial ovarian cancer (EOC) cells undergo epithelialto-mesenchymal transition (EMT), which influences metastatic success. Mutationdependent activation of Wnt/β-cateninExpand
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Prostaglandin F2α Stimulates the Raf/MEK1/Mitogen-Activated Protein Kinase Signaling Cascade in Bovine Luteal Cells.
Upon binding to its G protein-coupled transmembrane receptors, the actions of PGF2α on the corpus luteum are initiated by the phospholipase C/diacylglycerol-inositol 1,4,5-trisphosphateExpand
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Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
Signal transduction pathways associated with cancer progression and chemotherapeutic resistance are being investigated as molecular targets for chemotherapy. The phosphatidylinositol 3-kinase (PI3K)Expand
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