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The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease
TLDR
Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. Expand
Two Hybridization Events Define the Population Structure of Trypanosoma cruzi
TLDR
A model is proposed in which a fusion between ancestral DTU I and IIb strains gave rise to a heterozygous hybrid that homogenized its genome to become the homozygous progenitor of DTUs IIa and IIc, which resulted in the formation of the current DTUs. Expand
Comparative Genomics of Trypanosomatid Parasitic Protozoa
TLDR
No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed. Expand
A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
TLDR
It is found that the plant-like calcium-dependent protein kinase PfCDPK5, which is expressed in invasive merozoite forms of Plasmodium falciparum, was critical for egress from the human host erythrocyte, an essential step in the parasite life cycle. Expand
Evidence for multiple hybrid groups in Trypanosoma cruzi.
TLDR
Comparison of 10 regions of the genome from two isolates representing T. cruzi shows for the first time that IIa/IIc are hybrid, consistent with the hypothesis that genetic recombination has occurred more than once within the T.cruzi lines. Expand
Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes
TLDR
It is shown here that whole-genome analysis of the parasite can be achieved directly from ex vivo-isolated parasites, without the need for in vitro propagation, and provides a data set for comparative analysis with important potential for identifying markers for global parasite diversity and drug resistance mapping studies. Expand
A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito
TLDR
This work examined parasite transcriptional changes in samples from infected patients and mosquitoes in order to characterize gene function, define regulatory sequences and reveal new potential vaccine candidate genes, concluding that high-quality gene expression data can be readily obtained directly from patient samples and that many of the same uncharacterized genes that are up regulated in different P. vivax lifecycle stages are also upregulated in similar stages in other Plasmodium species. Expand
Trypanosomatid biodiversity in Costa Rica: genotyping of parasites from Heteroptera using the spliced leader RNA gene
TLDR
Only a minor fraction of the trypanosomatid biodiversity is revealed, which is anticipated to be high, and cluster analysis indicated that these typing units were unique and thus could represent new species and, in some cases, new genera. Expand
Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region
TLDR
The CL Brener and Esmeraldo maxicircles represent two of three previously defined maxicircle clades and promise utility as taxonomic markers. Expand
Diversity of Insect Trypanosomatids Assessed from the Spliced Leader RNA and 5S rRNA Genes and Intergenic Regions1
TLDR
The data revealed additional discrepancies between molecular phylogenetic data and cell morphology, rendering current trypanosomatid taxonomy unreliable, and several isolates seem to belong to a single species with an unexpectedly wide host and geographical range. Expand
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