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Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability
Summary Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in whichExpand
Circuitry and plasticity of the dorsal horn – Toward a better understanding of neuropathic pain
Maladaptive plasticity within the dorsal horn (DH) of the spinal cord is a key substrate for development of neuropathic pain following peripheral nerve injury. Advances in genetic engineering,Expand
A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
Transgenic mouse models expressing mutant superoxide dismutase 1 (SOD1) have been critical in furthering our understanding of amyotrophic lateral sclerosis (ALS). However, such models generallyExpand
Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn
Abstract Excitatory interneurons account for the majority of neurons in the superficial dorsal horn, but despite their presumed contribution to pain and itch, there is still limited information aboutExpand
Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations
Significance The mechanisms triggering motor and sensory nerve dysfunction in the genetically diverse Charcot–Marie–Tooth disease (CMT) remain unresolved, as does the reason for the lack of sensoryExpand
Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero
Gestational transfer of maternal antibodies against fetal neuronal proteins may be relevant to some neurodevelopmental disorders, but until recently there were no proteins identified. We recentlyExpand
Sensory processing of deep tissue nociception in the rat spinal cord and thalamic ventrobasal complex
Sensory processing of deep somatic tissue constitutes an important component of the nociceptive system, yet associated central processing pathways remain poorly understood. Here, we provide a novelExpand
Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Dorsal horn excitatory interneurons that express gastrin-releasing peptide (GRP) are part of the circuit for pruritogen-evoked itch. They have been extensively studied in a transgenic line in whichExpand
StereoMate: A Stereological and Automated Analysis Platform for Assessing Histological Labelling in Cleared Tissue Specimens
The recent resurgence of tissue clearing methods presents a number of challenges. Cleared tissue protocols remain refractory to complete immunofluorescence labelling, and demonstrating a reliable andExpand
Maternal CASPR2 antibodies and neurodevelopmental disorders in the offspring: epidemiological findings and an animal model
Abstract Background CNS disorders can be caused by IgG antibodies to neuronal surface proteins, and these antibodies have the potential to cross the placenta. Since some of them target proteinsExpand