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The molecular basis of asbestos induced lung injury
Asbestos causes progressive pulmonary fibrosis (asbestosis), pleural disease (effusion and pleural plaques), and malignancies such as bronchogenic carcinoma and malignant mesothelioma.1-3 Asbestos is… Expand
The role of free radicals in asbestos-induced diseases.
- D. Kamp, P. Graceffa, W. A. Pryor, S. Weitzman
- Chemistry, Medicine
- Free radical biology & medicine
Asbestos exposure causes pulmonary fibrosis and malignant neoplasms by mechanisms that remain uncertain. In this review, we explore the evidence supporting the hypothesis that free radicals and other… Expand
Mapping of ER gene CpG island methylation-specific polymerase chain reaction.
Southern analysis has shown that DNA from 25% of primary estrogen receptor (ER) alpha-negative breast tumors displays aberrant methylation at one site within the ER gene CpG island. To examine more… Expand
Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors.
- R. Lapidus, A. T. Ferguson, +6 authors N. Davidson
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 May 1996
Hormonal factors have a profound influence on the development, treatment, and outcome of breast cancer. The absence of steroid hormone receptors is highly correlated with resistance to antihormonal… Expand
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation.
Cyclin D2 is a member of the D-type cyclins, implicated in cell cycle regulation, differentiation, and malignant transformation. It was noted previously that cyclin D2 is not expressed in the… Expand
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.
We analyzed Wilms' tumor suppressor 1 (WT1) expression and its regulation by promoter methylation in a panel of normal breast epithelial samples and primary carcinomas. Contrary to previous reports,… Expand
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis.
We have reviewed some of the data that link the reactive oxygen species produced by inflammatory phagocytes to cancer development. While it is clear that these substances induce phenotypic changes… Expand
Free radical adducts induce alterations in DNA cytosine methylation.
- S. Weitzman, P. Turk, D. H. Milkowski, K. Kozłowski
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 15 February 1994
Methylation of cytosines in DNA is important for the regulation of expression of many genes. During carcinogenesis, normal patterns of gene methylation can be altered. Oxygen radical injury, shown to… Expand
DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase.
8-Hydroxyl-2'-deoxyguanosine (also referred to as 8-hydroxyguanine [8-OH-dG] or 7,8-dihydro-8-oxoguanine), a common DNA adduct resulting from injury to DNA via reactive oxygen species, affects the in… Expand
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide.
To understand chemical characteristics of the asbestos minerals which might contribute to tissue damage, the catalytic properties of three different varieties were studied. Using spin trapping… Expand