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Family‐based tests for associating haplotypes with general phenotype data: Application to asthma genetics
We provide a general purpose family‐based testing strategy for associating disease phenotypes with haplotypes when phase may be ambiguous and parental genotype data may be missing. These tests forExpand
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Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys.
BACKGROUND In 1995, the Global Initiative for Asthma (GINA) guidelines recommended goals for the management of asthma, which were updated in 2002. However, there are no recent international surveysExpand
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PBAT: tools for family-based association studies.
PBAT is a software package for family-based association studies that provides a software implementation of the approaches to analytical power calculations for FBATs, as well as data analysis of such studies. Expand
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The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol.
STUDY OBJECTIVE To compare the safety of salmeterol xinafoate or placebo added to usual asthma care. DESIGN A 28-week, randomized, double-blind, placebo-controlled, observational study. SETTINGExpand
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Estimation and Tests of Haplotype-Environment Interaction when Linkage Phase Is Ambiguous
In the study of complex traits, the utility of linkage analysis and single marker association tests can be limited for researchers attempting to elucidate the complex interplay between a gene andExpand
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Effects of obesity and fat distribution on ventilatory function: the normative aging study.
OBJECTIVE Although the influence of obesity on ventilatory function has long been recognized, the nature of the relationship and the mechanisms are not yet clear. The purpose of this report was toExpand
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Prospective study of body mass index, weight change, and risk of adult-onset asthma in women.
BACKGROUND Obesity and asthma are common disorders, and their prevalence rates continue to rise. Although individuals with asthma may gain weight as a result of activity limitations, the relationshipExpand
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Dietary antioxidant vitamin intake and lung function in the general population.
We have investigated the relation between lung function and dietary intake of the antioxidant vitamins C and E in the general population in a cross-sectional survey of a random sample of adults fromExpand
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The effect of maternal smoking during pregnancy on early infant lung function.
We studied the effect of prenatal maternal cigarette smoking on the pulmonary function (PF) of 80 healthy infants tested shortly after birth (mean, 4.2 +/- 1.9 wk). Mothers' prenatal smoking wasExpand
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Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study
Background: The rising prevalence of asthma in developed nations may be associated with the rising prevalence of obesity in these same nations. The relationship between body mass index (BMI) and theExpand
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