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Genome-wide association study of circulating vitamin D levels
Strong genome-wide significant associations with 25(OH)D are confirmed through meta-analysis with the GWAS data for GC, NADSYN1/DHCR7, CYP2R1 and CYP 2R1, but not C10orf88, the key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand. Expand
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295. Expand
Multiple loci identified in a genome-wide association study of prostate cancer
The findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals. Expand
Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine.
- S. Weinstein, T. Hartman, +5 authors D. Albanes
- Cancer epidemiology, biomarkers & prevention : a…
- 1 November 2003
Folate is necessary for DNA synthesis, repair, and methylation, and biological reactions involving folate require vitamins B6 and B12 as cofactors. Low concentrations of these vitamins can impair… Expand
Healthy Eating Index scores are associated with blood nutrient concentrations in the third National Health And Nutrition Examination Survey.
HEI score is correlated with a wide range of blood nutrients; the strongest relationships are with biomarkers of fruit and vegetable intake. Expand
Detectable clonal mosaicism and its relationship to aging and cancer
Large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. Expand
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases. Expand
PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3).
Common genetic variation in these two genes might play at best a limited role in breast and prostate cancers. Expand
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
- A. A. Al Olama, Z. Kote-Jarai, +161 authors C. Haiman
- Biology, Medicine
- Nature Genetics
- 14 September 2014
These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease. Expand
Adipokine genes and prostate cancer risk
Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis, andPolymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Expand