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The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
κ receptor agonists antagonize the reinforcing/rewarding effects of drugs possibly through punishing/aversive-like effects and reinstate drug seeking through stress- like effects and evidence suggests that abused drugs activate the κ opioid system, which may play a key role in motivational aspects of dependence.
Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs
- S. Wee, K. Anderson, M. Baumann, R. Rothman, B. Blough, W. Woolverton
- BiologyJournal of Pharmacology and Experimental…
- 1 May 2005
The results suggest that the mechanism for this effect involves a decrease in reinforcing potency and efficacy among monoamine releasing agents when 5-HT releasing potency is increased relative to DA.
Escalation of methamphetamine self-administration in rats: a dose–effect function
- O. Kitamura, S. Wee, Sheila E. Specio, G. Koob, L. Pulvirenti
- Biology, PsychologyPsychopharmacology
- 17 March 2006
The escalation of drug intake observed with extended access is produced at multiple doses of methamphetamine, suggesting that the rapidity of escalation is dependent on dose and has an upper limit of intake over a 21-day period.
Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell
It is demonstrated for the first time that ΔFosB and CaMKII engage in a cell-type- and brain-region-specific positive feedforward loop as a key mechanism for regulating the reward circuitry of the brain in response to chronic cocaine.
In Vivo Effects of Amphetamine Analogs Reveal Evidence for Serotonergic Inhibition of Mesolimbic Dopamine Transmission in the Rat
- M. Baumann, R. D. Clark, W. Woolverton, S. Wee, B. Blough, R. Rothman
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 April 2011
The findings are consistent with the hypothesis that 5-HT release dampens stimulant effects of amphetamine-type drugs, but further studies are required to address the precise mechanisms underlying this phenomenon.
Varied Access to Intravenous Methamphetamine Self-Administration Differentially Alters Adult Hippocampal Neurogenesis
Effect of Aripiprazole, a Partial Dopamine D2 Receptor Agonist, on Increased Rate of Methamphetamine Self-Administration in Rats with Prolonged Session Duration
- S. Wee, Zhixia Wang, W. Woolverton, L. Pulvirenti, G. Koob
- Biology, PsychologyNeuropsychopharmacology
- 28 February 2007
The present data suggest increased sensitivity of the dopaminergic system to aripiprazole in LgA rats compared with ShA rats, however, mechanisms other than downregulation of D2 DA receptors in the nucleus accumbens and the striatum may be responsible for the increasedsensitive function.
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine
The data suggest that increased motivation for cocaine in rats with extended access may be related to increased κ opioid activity and may contribute to compulsive use.
Effects of Dose and Session Duration on Cocaine Self-Administration in Rats
- S. Wee, Sheila E. Specio, G. Koob
- Psychology, BiologyJournal of Pharmacology and Experimental…
- 1 March 2007
The data suggest that cocaine self-administration increases at various doses with prolonged access and that an increase in the rate of responding is positively and inversely associated with session duration and unit dose, respectively.