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Generation of influenza A viruses entirely from cloned cDNAs.
TLDR
A new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs is described, which should be useful in viral mutagenesis studies and in the production of vaccines and gene therapy vectors. Expand
A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.
TLDR
Human cytomegalovirus (CMV), a herpesvirus that causes congenital disease and opportunistic infections in immunocompromised individuals, encodes functions that facilitate efficient viral propagation by altering host cell behavior and encodes a mitochondria-localized inhibitor of apoptosis, denoted vMIA, capable of suppressing apoptosis induced by diverse stimuli. Expand
Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors.
TLDR
This helper cell-vector system will be useful to derive infectious recombinant virus stocks of high titer (over 10(5) thymidine kinase transforming units per ml) which are able to infect avian, rat, and dog cells without the aid of helper virus. Expand
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
TLDR
The Philadelphia chromosome (Ph1), observed in greater than 90% of chronic myelogenous leukemia (CML) patients, results from a specific chromosomal translocation involving the c-abl gene, which results in the creation of a chimeric gene leading to the production of a structurally altered c-rab protein with activated tyrosine kinase activity. Expand
Mutational analysis of human papillomavirus type 16 E7 functions
TLDR
The data suggest that regions 1 to 3 are required for its functions and that the meta-binding motifs in region3 are required to maintain a stable or functional structure of the E7 protein. Expand
Pseudorabies virus early protein 0 transactivates the viral gene promoters.
TLDR
In transient expression assays, EP0 transactivated the PRV IE, thymidine kinase (TK) and glycoprotein X (gX) promoters, indicating that EP0, like ICP0 of HSV-1, is a transactivating protein. Expand
Human cytomegalovirus open reading frame UL11 encodes a highly polymorphic protein expressed on the infected cell surface
TLDR
It is reported here that ORF UL11 encodes a polymorphic protein expressed on the surface of HCMV-infected cells that contains variable amino acid residues protrudes from the infected cell surface. Expand
Genetic basis of the neurovirulence of pseudorabies virus
TLDR
The results show that genes in the US region, which are missing from the Bartha strain, were necessary for virulence but that this strain was also defective in other genes required for the expression of virulence. Expand
Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry.
TLDR
Results indicate that the GP ectodomain and its anchorage to the membrane are required for GP-induced morphologic changes in host cells, and suggest that integrins, especially the beta1 group, might interact with the GP and perhaps be involved in Ebola virus entry into cells. Expand
Characterization of the immediate-early functions of pseudorabies virus.
TLDR
It is concluded that pseudorabies virus codes for a single multifunctional immediate-early protein which is essential for the transcription of immediate- early to early RNA and is required for the continuous transcription of early (and late) RNA. Expand
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