S. Watanabe

Publications46
h-index15
Citations1,107
Highly Influential Citations51
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Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
Embryonic stem (ES) cells can self-renew indefinitely without losing their differentiation ability to any cell types. Phosphoinositide-3 kinase (PI3K)/Akt signaling plays a pivotal role in various… Expand
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Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering
Hepatocyte growth factor (HGF) markedly induced the spreading, dissociation and scattering of Madin–Darby canine kidney epithelial cells (MDCK) and human stomach adenocarcinoma cells (TMK1).… Expand
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Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine
The present study shows that various cytokines such as tumor necrosis factor (TNFα), interleukin-1α (IL-1α), and interferon-γ (IFNγ) make tumor cells much more susceptible to the cytostatic… Expand
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Distinct Mechanisms of α5β1 Integrin Activation by Ha-Ras and R-Ras*
To investigate the possible roles of the Ras/Rho family members in the inside-out signals to activate integrins, we examined the ability of Ras/Rho small GTPases to stimulate avidity of α5β1 (VLA-5)… Expand
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Design, construction, and analysis of a novel class of self-folding RNA.
RNA can play multiple biological roles through use of its three-dimensional (3-D) structures. Recent advances in RNA structural biology have revealed that complex RNA 3D structures are assemblages of… Expand
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Rapid real-time diagnostic PCR for Trichophyton rubrum and Trichophyton mentagrophytes in patients with tinea unguium and tinea pedis using specific fluorescent probes.
BACKGROUND Trichophyton rubrum and Trichophyton mentagrophytes human-type (synonym, Trichophyton interdigitale (anthropophilic)) are major causative pathogens of tinea unguium. For suitable diagnosis… Expand
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Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells.
Thiazolidinediones, activators of peroxisome proliferator-activated receptor (PPAR)gamma, have been reported to induce apoptosis in many types of cells. In the present study, we investigated the… Expand
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Subtypes of small cell carcinoma of the lung: morphometric, ultrastructural, and immunohistochemical analyses.
Fifty-three surgically resected small cell carcinomas of the lung were studied morphometrically, electron microscopically, immunohistochemically, and in terms of possible site of origin. Four… Expand
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High Expression of HuR in Cytoplasm, but Not Nuclei, Is Associated with Malignant Aggressiveness and Prognosis in Bladder Cancer
Introduction Human antigen R (HuR) regulates the stability of mRNA and is associated with cell proliferation, angiogenesis, and lymphangiogenesis. However, the clinical significance and pathological… Expand
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Clinical significance and predictive value of prostaglandin E2 receptors (EPR) 1 - 4 in patients with renal cell carcinoma.
BACKGROUND The clinical significance of prostaglandin E2 receptor (EPR) expression in renal cell carcinoma (RCC) tissues remains unclear. Patients and Μethods: Four subtypes of EPRs were examined in… Expand
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