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Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney
A monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium is described.
The importance of the Selberg integral
It has been remarked that a fair measure of the impact of Atle Selberg’s work is the number of mathematical terms that bear his name. One of these is the Selberg integral, an n-dimensional
Summation and transformation formulas for elliptic hypergeometric series
Using matrix inversion and determinant evaluation techniques we prove several summation and transformation formulas for terminating, balanced, very-well-poised, elliptic hypergeometric series.
Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule
It is demonstrated here that EGP40 is an epithelium-specific intercellular adhesion molecule that resembles to some extent the molecules of the immunoglobulin superfamily of cell adhesion molecules (CAMs), although no immunoglobeulin-like repeats are present in the EGP30 molecule.
Epithelial Cell Adhesion Molecule (Ep-CAM) Modulates Cell–Cell Interactions Mediated by Classic Cadherins
The ability of Ep-CAM to modulate the cadherin-mediated cell–cell interactions, as demonstrated in the present study, suggests a role for this molecule in development of the proliferative, and probably malignant, phenotype of epithelial cells.
Epidermal Growth Factor-Like Repeats Mediate Lateral and Reciprocal Interactions of Ep-CAM Molecules in Homophilic Adhesions
It is established that both EGF-like repeats are required for the formation of Ep-CAM-mediated homophilic adhesions, including the accumulation of Ep -CAM molecules at the cell-cell boundaries, and the anchorage of the Ep- CAM adhesion complex to F-actin via α-act inin.
Monoclonal antibody PAL-E specific for endothelium.
Based on immunoelectronmicroscopic observations, the antigenic determinant recognized by PAL-E is associated with endothelial vesicles and is a new staining reagent for endothelium in frozen sections.
Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation.
It is demonstrated that the expression of Ep-CAM in cervical squamous epithelium is associated with abnormal proliferation of cell populations that are not committed to terminal differentiation.