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The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting.
STUDY OBJECTIVE To evaluate the relationship between the adequacy of antimicrobial treatment for bloodstream infections and clinical outcomes among patients requiring ICU admission. DESIGNExpand
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Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients.
STUDY OBJECTIVE To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiringExpand
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Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia.
STUDY OBJECTIVES To determine the influence of initially delayed appropriate antibiotic treatment (IDAAT) on the outcomes of patients with ventilator-associated pneumonia (VAP). SETTING Medical ICUExpand
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The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia.
STUDY OBJECTIVE To determine the influence of mini-BAL culture results on subsequent changes in antibiotic therapy and patient outcomes. DESIGN Prospective, single-center, cohort study. SETTINGExpand
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Experience with a clinical guideline for the treatment of ventilator-associated pneumonia
Objective To evaluate a clinical guideline for the treatment of ventilator-associated pneumonia. Design Prospective before-and-after study design. Setting A medical intensive care unit from aExpand
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A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia.
OBJECTIVE To evaluate an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia (VAP). DESIGN Prospective, randomized, controlled clinical trial. SETTING AExpand
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A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting.
STUDY OBJECTIVE To compare the clinical outcomes of critically ill patients developing early-onset nosocomial pneumonia (NP; ie, within 96 h of ICU admission) and late-onset NP (ie, occurring afterExpand
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A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States.
BACKGROUND Current therapy for crotaline snakebite includes antivenin (Crotalidae) polyvalent, an antivenom with numerous adverse effects. We compared the efficacy and safety of 2 dosing regimensExpand
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Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices
ObjectiveThe purpose of this study was to determine the impact of scheduled changes of antibiotic classes, used for the empirical treatment of suspected or documented Gram-negative bacterialExpand
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Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa.
STUDY OBJECTIVES To evaluate the relationship between hospital mortality and bloodstream infections due to Staphylococcus aureus or Pseudomonas aeruginosa. DESIGN Prospective cohort study. Expand
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