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The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting.
TLDR
The data suggest that clinical efforts should be aimed at reducing the administration of inadequate antimicrobial treatment to hospitalized patients with bloodstream infections, especially individuals infected with antibiotic-resistant bacteria and Candida species.
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients.
TLDR
Inadequate treatment of infections among patients requiring ICU admission appears to be an important determinant of hospital mortality, and clinical efforts aimed at reducing the occurrence of inadequate antimicrobial treatment could improve the outcomes of critically ill patients.
Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia.
TLDR
Clinicians should avoid delaying the administration of appropriate antibiotic treatment to patients with VAP in order to minimize their risk of mortality.
The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia.
TLDR
It is suggested that antibiotic selection prior to obtaining the results of lower airway cultures is an important determinant of outcome for patients with suspected VAP, and a delay in initiating adequate antibiotic therapy was associated with a greater mortality.
Experience with a clinical guideline for the treatment of ventilator-associated pneumonia
TLDR
The application of a clinical guideline for the treatment of ventilator-associated pneumonia can increase the initial administration of adequate antimicrobial treatment and decrease the overall duration of antibiotic treatment.
A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia.
TLDR
The application of an antibiotic discontinuation policy for clinically suspected VAP was associated with a decrease in the overall duration of antibiotic treatment, suggesting that shorter courses of empiric antibiotic therapy for patients treated for clinically suspect VAP can be safely achieved.
A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting.
TLDR
The data suggest that P aeruginosa and ORSA can be important pathogens associated with early-onset NP in the ICU setting, and clinicians should be aware of the common microorganisms associated with both early-ONSet NP and late-onsett NP in their hospitals in order to avoid the administration of inadequate antimicrobial treatment.
A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States.
TLDR
In the first randomized trial of antivenom in the United States, Fab AV effectively terminated venom effects and since the unplanned use of Fab AV in the PRN group was common, the treatment regimen may require more than 1 initial dose.
Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices
TLDR
Reducing inadequate antibiotic administration may improve the outcomes of critically ill patients with APACHE II scores ≥15 and suggest that scheduled changes of antibiotic classes for the empirical treatment of Gram-negative bacterial infections can reduce the occurrence of inadequate antibiotic treatment for nosocomial infections.
Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa.
TLDR
It is suggested that bloodstream infections due to P aeruginosa have a greater risk of hospital mortality compared to bloodstream infectionsDue to S aureus despite adequate antibiotic treatment.
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