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Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.
- G. Suntharalingam, M. Perry, +4 authors N. Panoskaltsis
- The New England journal of medicine
- 7 September 2006
Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 monoclonal antibody that directly… Expand
Fundamental uncertainties in projects and the scope of project management
This paper builds on discussions that took place over a series of meetings in the UK of the Rethinking Project Management Network. The management of uncertainty is seen as a necessary condition for… Expand
Artemisinins target the SERCA of Plasmodium falciparum
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum. Artemisinins are… Expand
Chloroquine resistance before and after its withdrawal in Kenya
BackgroundThe spread of resistance to chloroquine (CQ) led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal was followed by a rapid… Expand
Access to hematin: the basis of chloroquine resistance.
The saturable uptake of chloroquine by parasites of Plasmodium falciparum has been attributed to specific carrier-mediated transport of chloroquine. It is suggested that chloroquine is transported in… Expand
Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria
- R. McGready, K. Stepniewska, +5 authors F. Nosten
- European Journal of Clinical Pharmacology
- 22 March 2006
ObjectiveTo determine the pharmacokinetic properties of dihydroartemisinin (DHA) following oral artesunate treatment in women with recrudescent multi-drug resistant falciparum malaria, in the second… Expand
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the… Expand
Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.
- R. Clark, T. E. White, Sally A Clode, Ian F. Gaunt, P. Winstanley, S. Ward
- Birth defects research. Part B, Developmental and…
- 1 December 2004
The artemisinins are playing an increasingly important role in treating multidrug-resistant malaria. The artemisinin, artesunate, is currently in use in Southeast Asia and is advocated for use in… Expand
Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria
- G. Biagini, P. Viriyavejakul, P. O'Neill, P. Bray, S. Ward
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 May 2006
ABSTRACT This study reports on the first characterization of the alternative NADH:dehydrogenase (also known as alternative complex I or type II NADH:dehydrogenase) of the human malaria parasite… Expand
Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP
Background:The efflux transporters P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRP) and breast cancer resistance protein (BCRP) limit the accumulation of antiretrovirals in cell… Expand