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Human embryonic germ cells isolation from early stages of post-implantation embryos
Human embryonic germ (hEG) cell is a very important alternative pluripotent stem cell resource. We describe the derivation of hEG cells from human embryonic fetal gonads over 6–8 weeksExpand
Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.
BACKGROUND/AIMS Myofibroblasts play a central role in the pathogenesis of liver fibrosis. Myofibroblasts of bone marrow (BM) origin have recently been identified in fibrotic liver. However, little isExpand
The Egf Receptor‐Sox2‐Egf Receptor Feedback Loop Positively Regulates the Self‐Renewal of Neural Precursor Cells
The transcriptional factor Sox2 and epidermal growth factor receptor (Egfr)‐mediated signaling are both required for self‐renewal of neural precursor cells (NPCs). However, the mechanism by whichExpand
Nek2A contributes to tumorigenic growth and possibly functions as potential therapeutic target for human breast cancer
Nek2A (NIMA‐related kinases 2A) has been known as an important centrosome regulatory factor. The aim of this study was to investigate the expression of Nek2A and the role it played in differentExpand
A retrospective study of breast cancer subtypes: the risk of relapse and the relations with treatments
Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate relapse for patientsExpand
Abnormal expression of Nek2 and β‐catenin in breast carcinoma: clinicopathological correlations
Wang S, Li W, Lv S, Wang Y, Liu Z, Zhang J, Liu T & Niu Y
(2011) Histopathology59, 631–642
FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells
FTY720 is a novel immunosuppressant that modulates sphingosine 1-phosphate (S1P) receptors for the treatment of several diseases. Several hallmarks of liver fibrosis are influenced by S1P, and theExpand
Mechanism of riboflavin uptake by cultured human retinal pigment epithelial ARPE‐19 cells: possible regulation by an intracellular Ca2+–calmodulin‐mediated pathway
In mammalian cells (including those of the ocular system), the water‐soluble vitamin B2 (riboflavin, RF) assumes an essential role in a variety of metabolic reactions and is critical for normalExpand
Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells
The recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) to damaged tissues and sites of inflammation is an essential step for clinical therapy. However, the signals regulating theExpand
Pax6 directly modulate Sox2 expression in the neural progenitor cells
Pax6 is a key regulator in the neuronal fate determination as well as the proliferation of neural stem cells, but the mechanisms are still unknown. Our study shows that Pax6 regulate theExpand