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Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the… Expand
Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study.
Mesenchymal stem cells (MSCs) have been isolated from the pulp tissue of permanent teeth (dental pulp stem cells or DPSCs) and deciduous teeth (stem cells from human exfoliated deciduous teeth). We… Expand
The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering.
- G. T. Huang, W. Sonoyama, Y. Liu, H. Liu, S. Wang, S. Shi
- Materials Science, Medicine
- Journal of endodontics
- 1 June 2008
Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment. A call for a paradigm… Expand
Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity
- Fulan Wei, Cunye Qu, +7 authors S. Wang
- Biology, Medicine
- Journal of cellular physiology
- 1 September 2012
Cell sheet engineering has been developed as an alternative approach to improve mesenchymal stem cell‐mediated tissue regeneration. In this study, we found that vitamin C (Vc) was capable of inducing… Expand
Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
- T. Yamaza, Akiyama Kentaro, +5 authors S. Shi
- Biology, Medicine
- Stem Cell Research & Therapy
- 15 March 2010
IntroductionStem cells from human exfoliated deciduous teeth (SHED) have been identified as a population of postnatal stem cells capable of differentiating into osteogenic and odontogenic cells,… Expand
Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome.
Sjögren syndrome (SS) is a systemic autoimmune disease characterized by dry mouth and eyes, and the cellular and molecular mechanisms for its pathogenesis are complex. Here we reveal, for the first… Expand
Cell-Based Immunotherapy With Mesenchymal Stem Cells Cures Bisphosphonate-Related Osteonecrosis of the Jaw–like Disease in Mice
- T. Kikuiri, I. Kim, +8 authors S. Shi
- Journal of bone and mineral research : the…
- 29 January 2010
Patients on high‐dose bisphosphonate and immunosuppressive therapy have an increased risk of bisphosphonate‐related osteonecrosis of the jaw (BRONJ); despite the disease severity, its pathophysiology… Expand
Periodontal Ligament Stem Cell‐Mediated Treatment for Periodontitis in Miniature Swine
Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke,… Expand
Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells.
Stem cells from human exfoliated deciduous teeth (SHED) have been identified as a novel population of postnatal stem cells capable of differentiating into neural cells, odontogenic cells, and… Expand
Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine
Periodontitis is one of the most widespread infectious diseases in humans. It is the main cause of tooth loss and associated with a number of systemic diseases. Until now, there is no appropriate… Expand