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Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
Background:Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial injury due to ischemia that occurs during or within 30 days after noncardiac surgery.Expand
Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues.
OBJECTIVE Clinical testing for vitamin D nutritional status has experienced tremendous growth in the past several years, driven by research results linking various diseases with low serumExpand
Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension
To the Editor: Noninvasive biomarkers are needed to aid in making challenging clinical decisions in pulmonary arterial hypertension (PAH). Several biomarkers have been described, but only theExpand
Sensitive measurement of serum 1α,25-dihydroxyvitamin D by liquid chromatography/tandem mass spectrometry after removing interference with immunoaffinity extraction.
Vitamin D plays important roles in bone health and a variety of other pathophysiological conditions. 1α,25-Dihydroxyvitamin D is the active form of vitamin D. Quantification of serumExpand
Breath analysis in pulmonary arterial hypertension.
BACKGROUND Pulmonary arterial hypertension (PAH) is a progressive and devastating condition characterized by vascular cell proliferation and is associated with several metabolic derangements. WeExpand
Epidemiology of vitamin D in health and disease
  • S. Wang
  • Medicine
  • Nutrition Research Reviews
  • 28 October 2009
Results from ecological, case–control and cohort studies have shown that vitamin D reduces the risk of bone fracture, falls, autoimmune diseases, type 2 diabetes, CVD and cancer. However, there isExpand
Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin‐bound vitamin B12
Elevated methylmalonic acid in five asymptomatic newborns whose fibroblasts showed decreased uptake of transcobalamin‐bound cobalamin (holo‐TC), suggested a defect in the cellular uptake ofExpand
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous quantitation of 5 azole antifungals and 1 active metabolite.
  • A. McShane, S. Wang
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of…
  • 1 November 2017
BACKGROUND Azole antifungal medications are often administered to prevent or treat invasive fungal infections. These infections are deadly in the immunocompromised population. Therapeutic drugExpand
Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers
Objectives In the United States, minimum standards for quality control (QC) are specified in federal law under the Clinical Laboratory Improvement Amendment and its revisions. Beyond meeting thisExpand
Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.
The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that theExpand