Eicosanoids in preeclampsia.
- S. Walsh
- MedicineProstaglandins, Leukotrienes and Essential Fatty…
- 1 February 2004
Preeclampsia: an imbalance in placental prostacyclin and thromboxane production.
- S. Walsh
- Medicine, BiologyAmerican Journal of Obstetrics and Gynecology
- 1 June 1985
Antioxidant Activities and mRNA Expression of Superoxide Dismutase, Catalase, and Glutathione Peroxidase in Normal and Preeclamptic Placentas
- Yuping Wang, S. Walsh
- MedicineJournal of the Society for Gynecologic…
- 1 July 1996
Activities of CuZn-SOD and GSH-Px and the tissue levels of vitamin E are significantly lower in preeclamptic placenta than in normal placentas, and it is speculated that decreased antioxidant activity may result in increased lipid peroxide levels in pree clampsia.
Placental isoprostane is significantly increased in preeclampsia
- S. Walsh, J. Vaughan, Y. Wang, L. Roberts
- Biology, MedicineThe FASEB Journal
- 1 July 2000
New information that isoprostanes are formed and secreted by the human placenta is presented and provides convincing evidence that oxidative stress and lipid peroxidation are abnormally increased in placentas of preeclamptic women.
Obesity: a risk factor for preeclampsia
- S. Walsh
- Medicine, BiologyTrends in endocrinology and metabolism
- 1 December 2007
Fetal and postnatal development of the adrenal glands in Macaca mulatta.
- W. McNulty, M. Novy, S. Walsh
- MedicineBiology of Reproduction
- 1 December 1981
LIPID PEROXIDATION IN PREGNANCY
- S. Walsh
- Biology, Chemistry
- 1994
In women with preeclampsia, circulating levels of lipid peroxides are increased, but net antioxidant activity is decreased as compared to normally pregnant women.
A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia.
- C. Qiu, D. Luthy, Cuilin Zhang, S. Walsh, W. Leisenring, M. Williams
- MedicineAmerican Journal of Hypertension
- 1 February 2004
Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia.
It is concluded that increased superoxide generation was associated with decreased SOD activity and mRNA expression for CuZn-SOD in trophoblast cells isolated from pre-eclamptic placentae, which support the notion of increased oxidative stress in the pre- eclamaptic placenta, which may contribute to the pathophysiology of this pregnancy disorder.
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