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Clinical pharmacology of buprenorphine: Ceiling effects at high doses
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone.
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Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis
TLDR
It is suggested that oral CBD does not reduce the reinforcing, physiological, or positive subjective effects of smoked cannabis, as well as the effect of oral THC on smoked cannabis administration.
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Acute administration of buprenorphine in humans: partial agonist and blockade effects.
TLDR
There is a ceiling on the effects of buprenorphine in humans that may reduce its abuse liability and increase its safety, and indicate that opioid blockade occurs after acute administration of bu p.o.m. or methadone.
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Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society.
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A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
TLDR
As compared with low-dose methadone, levomethadyl acetate, buprenorphine, and high-dose Methadone substantially reduce the use of illicit opioids.
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Signal of increased opioid overdose during COVID-19 from emergency medical services data
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The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers.
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Enadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humans.
TLDR
The data suggest that these kappa-agonists may be safely administered in the presence of cocaine but do not produce significant attenuation of cocaine's direct effects or self-administration under these acute dosing conditions.
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Gabapentin misuse, abuse and diversion: a systematic review.
TLDR
Empirical and case report evidence suggests that the anti-epileptic and analgesic medication gabapentin is being misused internationally, with substance abuse populations at special risk for misuse/abuse.
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Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans
TLDR
The pharmacodynamic effects of enadoline significantly increased measures of sedation, confusion and dizziness, produced visual distortions and feelings of depersonalization, and increased urinary output, and the highest dose was not tolerated and led to psychotomimetic effects.
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