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International network of cancer genome projects
The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical andExpand
DataSHIELD: taking the analysis to the data, not the data to the analysis
Background: Research in modern biomedicine and social science requires sample sizes so large that they can often only be achieved through a pooled co-analysis of data from several studies. But theExpand
DataSHIELD: resolving a conflict in contemporary bioscience—performing a pooled analysis of individual-level data without sharing the data
Background Contemporary bioscience sometimes demands vast sample sizes and there is often then no choice but to synthesize data across several studies and to undertake an appropriate pooled analysis.Expand
Data Safe Havens in health research and healthcare
TLDR
We propose 12 criteria that ought reasonably to be met by a data repository if it is to be seen as consistent with this interpretation and viewed as worthy of being accorded the status of Data Safe Haven. Expand
Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group
Abstract It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in cancer susceptibility genes identified onExpand
Emerging Regulatory Issues for Human Stem Cell Medicine1
The regulation of stem cell research is an issue that has drawn much comment, criticism and even judicial arbitration in recent years. An emerging issue, addressed in this article, is how the fruitsExpand
Prepublication data sharing
TLDR
Rapid release of prepublication release of sequencing data has served the field of genomics well. Expand
Genomic cloud computing: legal and ethical points to consider
TLDR
The biggest challenge in twenty-first century data-intensive genomic science, is developing vast computer infrastructure and advanced software tools to perform comprehensive analyses of genomic data sets for biomedical research and clinical practice. Expand
Are 'pseudonymised' data always personal data? Implications of the GDPR for administrative data research in the UK
TLDR
We argue that the definition of pseudonymisation in Article 4(5) GDPR will not expand the category of personal data, and that there is no intention that it should do so. Expand
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