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High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.
Pathophysiological parameters such as vascular density and tissue oxygen pressure can influence tumor malignancy and patient survival. Observations from our group showed that metastatic spread ofExpand
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Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 trimethylationExpand
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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumorExpand
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ERGO: A pilot study of ketogenic diet in recurrent glioblastoma
Limiting dietary carbohydrates inhibits glioma growth in preclinical models. Therefore, the ERGO trial (NCT00575146) examined feasibility of a ketogenic diet in 20 patients with recurrentExpand
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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
PURPOSE Hypoxia shifts the balance of cellular energy production toward glycolysis with lactate generation as a by-product. Quantitative bioluminescence imaging allows for the quantitation of lactateExpand
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Lactate: mirror and motor of tumor malignancy.
A number of studies have shown that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitativeExpand
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Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.
In solid malignant tumors, lactate has been identified as a prognostic parameter for metastasis and overall survival of patients. To investigate the effects of lactate on tumor cell migration, BoydenExpand
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Correlation of high lactate levels in head and neck tumors with incidence of metastasis.
Using quantitative bioluminescence imaging, tissue concentrations of ATP, glucose, and lactate were registered in biopsies that were taken from primary tumors of human head and neck at the time ofExpand
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Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology.
A number of studies have demonstrated that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitativeExpand
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Metabolic Imaging in Multicellular Spheroids of Oncogene-transfected Fibroblasts
Four rat embryo fibroblast (REF) cell lines with defined oncogenic transformation were used to study the relationship between tumorigenic conversion, metabolism, and development of cell death in a 3DExpand
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