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Vesicle-Mediated Export and Assembly of Pore-Forming Oligomers of the Enterobacterial ClyA Cytotoxin
The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells, but it has remained unknown how ClyA isExpand
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Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors
Membranes allow the compartmentalization of biochemical processes and are therefore fundamental to life. The conservation of the cellular membrane, combined with its accessibility to secretedExpand
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A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles
We discovered a new small non‐coding RNA (sRNA) gene, vrrA of Vibrio cholerae O1 strain A1552. A vrrA mutant overproduces OmpA porin, and we demonstrate that the 140 nt VrrA RNA represses ompAExpand
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Vibrio cholerae O1 Strain TSI-4 Produces the Exopolysaccharide Materials That Determine Colony Morphology, Stress Resistance, and Biofilm Formation
ABSTRACT Vibrio cholerae O1 strain TSI-4 (El Tor, Ogawa) can shift to a rugose colony morphology from its normal translucent colony morphology in response to nutrient starvation. We have investigatedExpand
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Quorum Sensing Regulation of the Two hcp Alleles in Vibrio cholerae O1 Strains
Background The type VI secretion system (T6SS) has emerged as a protein secretion system important to several Gram-negative bacterial species. One of the common components of the system is Hcp,Expand
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Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen.
We have characterized and cloned newly isolated lectins from hemolymph plasma of the horseshoe crab Tachypleus tridentatus, which we named tachylectins 5A and 5B (TLs-5). TLs-5 agglutinated all typesExpand
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The iron-binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni.
We identified and characterized the iron-binding protein Dps from Campylobacter jejuni. Electron microscopic analysis of this protein revealed a spherical structure of 8.5 nm in diameter, with anExpand
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Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni
BackgroundBackground: Cytolethal distending toxin (CDT) is one of the well-characterized virulence factors of Campylobacter jejuni, but it is unknown how CDT becomes surface-exposed or is releasedExpand
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A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing.
Vibrio cholerae is the causal bacterium of the diarrheal disease cholera, and its growth and survival are thought to be curtailed by bacteriovorous predators, e.g., ciliates and flagellates. WeExpand
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Biochemical and functional characterization of Helicobacter pylori vesicles
Helicobacter pylori can cause peptic ulcer disease and/or gastric cancer. Adhesion of bacteria to the stomach mucosa is an important contributor to the vigour of infection and resulting virulence. H.Expand
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