S. Wahyuono

Publications136
h-index11
Citations1,014
Highly Influential Citations32
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Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.
TLDR
Four new manzamine-type alkaloids were isolated from three collections of an Indonesian sponge of the genus Acanthostrongylophora and showed significant inhibitory activity of GSK3, an enzyme implicated in Alzheimer's disease pathology.
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In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllanthus niruri L. herbs traditionally used to treat malaria in Indonesia.
In endemic areas where malaria is prevalent, medicinal plants are often used to treat malaria. This study was conducted to evaluate the in vitro and in vivo antiplasmodial activity and cytotoxicity…
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Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
TLDR
Results suggest that manzamine A constitutes a promising scaffold from which more potent and selective GSK-3 inhibitors could be designed as potential therapeutic agents for Alzheimer's disease.
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Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.
TLDR
The biological activities and structure-activity relationship of the manzamines against malaria, Mycobacterium tuberculosis, Leishmania, HIV-1, and AIDS opportunistic infections are discussed and a plausible pathway for the formation of the 12,34-oxaether bridge in compound 3 is provided.
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Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
TLDR
Two novel alkaloids, named manadomanzamines A and B, were isolated from an Indonesian sponge and showed strong activity against Mycobacterium tuberculosis and human immunodeficiency virus and AIDS opportunistic fungal infections.
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New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and…
TLDR
Oral and intravenous pharmacokinetic studies of manzamine A in rats indicated the compound to have low metabolic clearance, a reasonably long pharmacokinetics half-life, and good absolute oral bioavailability of 20.6%, which supports the value of these compounds as potential leads for further preclinical assessment and possible development.
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Antiviral and Anticancer Optimization Studies of the DNA‐binding Marine Natural Product Aaptamine
TLDR
Aaptamine was evaluated for its ability to bind to DNA to validate DNA binding as the primary mechanism of cytotoxicity and its derivatives’ whole cell and viral assay results are discussed.
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Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia.
TLDR
The result suggests that vitexicarpin is able to block effects of histamine released from sensitized mast cells possibly by stabilizing the mast cells membrane function.
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Screening of several Indonesian medicinal plants for their inhibitory effect on histamine release from RBL-2H3 cells.
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A bioactive compound isolated from Duku ( Lansium domesticum Corr) fruit peels exhibits cytotoxicity against T47D cell line.
TLDR
To investigate the potential of the natural compound Lamesticumin A derived from L. domesticum fruit peel as an anticancer therapy, three samples of fruit peels of Duku were isolated to assess their cytotoxic nature against T47D cells.
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