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Nanocarriers in ocular drug delivery: an update review.
Controlled drug delivery to eye is one of the most challenging fields of pharmaceutical research. Low drug-contact time and poor ocular bioavailability due to drainage of solution, tear turnover and… Expand
Tamoxifen-loaded lecithin organogel (LO) for topical application: Development, optimization and characterization.
- A. Bhatia, B. Singh, K. Raza, S. Wadhwa, O. Katare
- Materials Science, Medicine
- International journal of pharmaceutics
- 28 February 2013
Lecithin organogels (LOs) are semi-solid systems with immobilized organic liquid phase in 3-D network of self-assembled gelators. This paper attempts to study the various attributes of LOs, starting… Expand
Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne.
- K. Raza, B. Singh, Parteek Singal, S. Wadhwa, O. Katare
- Colloids and surfaces. B, Biointerfaces
- 1 May 2013
Isotretinoin (ITR) is a drug of choice in the treatment of all types of acne, including recalcitrant, severe and nodulocystic. The most widely employed route of its administration, i.e., oral intake,… Expand
Hyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: development, characterization, and evaluation
In clinical practices, solution of dorzolamide hydrochloride (DH) and timolol maléate (TM) is recommended for the treatment of glaucoma. However, low drug-contact time and poor ocular bioavailability… Expand
Chitosan and its role in ocular therapeutics.
- S. Wadhwa, R. Paliwal, S. Paliwal, S. Vyas
- Biology, Medicine
- Mini reviews in medicinal chemistry
- 30 November 2009
From the past few decades, tremendous awareness has been laid on the use of natural polymers in ocular drug delivery. Chitosan, a modified natural carbohydrate polymer, has number of applications in… Expand
Phospholipid vesicles encapsulated bacteriophage: A novel approach to enhance phage biodistribution.
- S. Singla, K. Harjai, K. Raza, S. Wadhwa, O. Katare, S. Chhibber
- Biology, Medicine
- Journal of virological methods
- 1 October 2016
Phage therapy has been at the centre of attraction for combating multi-drug resistant strains. However, less stability and rapid clearance of phage by mononuclear phagocytic system (MPS) restricts… Expand
Dermatokinetics as an Important Tool to Assess the Bioavailability of Drugs by Topical Nanocarriers.
BACKGROUND Now-a-days, numerous nanocarrier-based drug products for topical applications are present in the market and number of similar products are being researched. To estimate the amount of drug… Expand
Novel phospholipid-based topical formulations of tamoxifen: evaluation for antipsoriatic activity using mouse-tail model
- A. Bhatia, B. Singh, S. Wadhwa, K. Raza, O. Katare
- Chemistry, Medicine
- Pharmaceutical development and technology
- 1 March 2014
Abstract Objective: Tamoxifen (TAM) is widely employed in the treatment of breast malignancies and is also found to be effective in psoriasis treatment. The current studies aimed to explore the… Expand
Coadministration of Polypeptide-k and Curcumin Through Solid Self-Nanoemulsifying Drug Delivery System for Better Therapeutic Effect Against Diabetes Mellitus: Formulation, Optimization,…
- V. Garg, P. Kaur, +9 authors S. Wadhwa
- Chemistry, Medicine
- Assay and drug development technologies
- 6 June 2019
An attempt has been made to prepare solid self-nanoemulsifying drug delivery system (SNEDDS) of polypeptide-k (PPK) and curcumin (CRM) using Labrafil M1944 CS as oil, Tween-80 as surfactant,… Expand
Impact of solid carriers and spray drying on pre/post-compression properties, dissolution rate and bioavailability of solid self-nanoemulsifying drug delivery system loaded with simvastatin
Abstract In the present study, different solid self-nanoemulsifying drug delivery system (S-SNEDDS) was formulated by using porous hydrophilic and hydrophobic carriers to improve the dissolution rate… Expand