• Publications
  • Influence
Assessing the probability that a positive report is false: an approach for molecular epidemiology studies.
TLDR
This commentary shows how to assess the FPRP and how to use it to decide whether a finding is deserving of attention or "noteworthy" and shows how this approach can lead to improvements in the design, analysis, and interpretation of molecular epidemiology studies.
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
TLDR
The risks of breast cancer may be overestimated, but they fall well below previous estimates based on subjects from high-risk families.
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
TLDR
Four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer were identified and confirmed in 1,776 affected individuals and 2,072 controls from three additional studies.
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly.
TLDR
Higher circulating levels of interleukin-6 and C-reactive protein were associated with mortality in this population-based sample of healthy older persons, and these measures may be useful for identification of high-risk subgroups for anti-inflammatory interventions.
Human papillomavirus and cervical cancer
TLDR
The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology, and can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings.
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
TLDR
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.
The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice.
TLDR
HPV screening that distinguishes HPV16 and HPV18 from other oncogenic HPV types may identify women at the greatest risk of > or = CIN3 and may permit less aggressive management of other women with onCogenic HPV infections.
Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival
TLDR
This work provides insight into the smoking-related mechanisms of lung neoplasia, and shows that the very mitotic genes known to be involved in cancer development are induced by smoking and affect survival.
Multiple loci identified in a genome-wide association study of prostate cancer
TLDR
The findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals.
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
TLDR
Using reported GWAS findings for height, Crohn's disease and breast, prostate and colorectal cancers, it is determined that each of these traits is likely to harbor additional loci within the spectrum of low-penetrance common variants.
...
1
2
3
4
5
...