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A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut.
The murine Hoxb-1 gene contains a homeobox sequence and is expressed in a spatiotemporal specific pattern in neuroectoderm, mesoderm and gut endoderm during development. We previously identified aExpand
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Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice
Expression of vertebrate Hox genes is regulated by retinoids such as retinoic acid (RA) in cell culture and in early embryonic development. Retinoic acid response elements (RAREs) have beenExpand
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Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos
In frog and zebrafish, the Mix/Bix family of paired type homeodomain proteins play key roles in specification and differentiation of mesendoderm. However, in mouse, only a single Mix gene (mMix) hasExpand
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2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits luminal cell differentiation and androgen responsiveness of the ventral prostate without inhibiting prostatic 5alpha-dihydrotestosterone formation or
In utero and lactational exposure to a single maternal dose of 1 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg causes some overt toxicity and impairs prostate growth in male offspring. AsExpand
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Human ovarian theca cells are a source of renin.
  • Y. Do, A. Sherrod, +5 authors W. Hsueh
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 March 1988
Human ovarian follicular fluid contains renin-like activity. In normal women, circulating levels of prorenin, the biosynthetic precursor of renin (EC 3.4.23.15), change in parallel with changes inExpand
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An extracellular matrix molecule that is selectively expressed during development is important for gastrulation in the sea urchin embryo.
The extracellular matrix is important in the regulation of many cellular events of early development including migration, shape change, proliferation and gene expression. In the sea urchin embryo,Expand
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Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene.
Mix/Bix proteins represent a vertebrate subgroup of paired-like homeodomain proteins which are known to function around the time of gastrulation. Here we report the structures of the genomic andExpand
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Cytokine regulation of HIV-1 LTR transactivation in human hepatocellular carcinoma cell lines.
Human hepatocellular carcinoma (HCC) cell lines, HEP-G2, J5, and SK-HEP-1, which differ in their differentiation status, were compared for their trans-activating activities after treatment withExpand
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Transient, Localized Accumulation of α-Spectrin during Sea Urchin Morphogenesis
Abstract The mRNA and protein of α-spectrin in the sea urchin embryo is shown here to be transiently overexpressed in cells initiating certain morphogenetic changes. This expression was detected byExpand
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Endoderm Differentiationin VitroIdentifies a Transitional Period for Endoderm Ontogeny in the Sea Urchin Embryo
Abstract The vegetal plate of the sea urchin embryo is specified during early cleavage divisions of the embryo as shown by the classical experiments of Horstadius (reviewed in “ExperimentalExpand
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