S. W. Chan

Publications24
h-index18
Citations2,468
Highly Influential Citations206
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A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.
TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role in the migration, invasion,… Expand
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The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmic… Expand
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Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In this report, we describe an independent… Expand
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Structural basis of YAP recognition by TEAD4 in the hippo pathway.
The Hippo signaling pathway controls cell growth, proliferation, and apoptosis by regulating the expression of target genes that execute these processes. Acting downstream from this pathway is the… Expand
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Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is… Expand
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AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
Yes-associated protein (YAP) is a downstream effector of the Hippo signaling pathway, which controls organ expansion and tissue development. We have recently defined the tumorigenic potential and… Expand
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TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*
The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in invasive breast… Expand
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WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ
The transcriptional co-activators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. YAP and TAZ both possess WW domains, which are important protein–protein… Expand
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Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations of Merlin have been… Expand
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Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation*
Background: LATS kinase, one of the core kinases of Hippo pathway, phosphorylates and inactivates the downstream coactivator YAP/TAZ. Results: The angiomotin (Amot) family members are phosphorylated… Expand
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