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Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection
While people infected with Leishmania can become refractory to reinfection, human vaccines have not yet been achieved. Glennie et al. identify a population of skin-resident Leishmania-specific memoryExpand
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Smad-Runx Interactions During Chondrocyte Maturation
Background: Intracellular signaling triggered by bone morphogenetic proteins (BMPs) results in activated Smad complexes that regulate transcription of BMP-responsive genes. However, the lowExpand
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Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs
Dogs with mucopolysaccharidosis VII (MPS VII) were injected intravenously at 2–3 days of age with a retroviral vector (RV) expressing canine β-glucuronidase (cGUSB). Five animals received RV alone,Expand
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IL-33-dependent group 2 innate lymphoid cells promote cutaneous wound healing
Breaches in the skin barrier initiate an inflammatory immune response that is critical for successful wound healing. Innate lymphoid cells (ILCs) are a recently identified population of immune cellsExpand
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Regenerative healing, scar‐free healing and scar formation across the species: current concepts and future perspectives
All species have evolved mechanisms of repair to restore tissue function following injury. Skin scarring is an inevitable and permanent endpoint for many postnatal organisms except for non‐amnioteExpand
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Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.
Cutaneous wounds establish endogenous "wound current" upon injury until re-epithelialization is complete. Keratinocyte proliferation, regulated partly by p53, is required for epidermal closure. SIVA1Expand
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A BMP responsive transcriptional region in the chicken type X collagen gene.
Bone morphogenetic proteins (BMPs) were originally identified by their ability to induce ectopic bone formation and have been shown to promote both chondrogenesis and chondrocyte hypertrophy. BMPsExpand
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Effects of Donor Characteristics and Ex Vivo Expansion on Canine Mesenchymal Stem Cell Properties: Implications for MSC-Based Therapies
Clinical trials utilizing bone marrow-derived mesenchymal stem cell (BM-MSC) therapies show promise for treating a variety of pathologic conditions. Paramount to optimization of such cell-basedExpand
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A BMP responsive transcriptional region in the chicken type X collagen gene.
Bone morphogenetic proteins (BMPs) were originally identified by their ability to induce ectopic bone formation and have been shown to promote both chondrogenesis and chondrocyte hypertrophy. BMPsExpand
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Diminished Type III Collagen Promotes Myofibroblast Differentiation and Increases Scar Deposition in Cutaneous Wound Healing
The repair of cutaneous wounds in the postnatal animal is associated with the development of scar tissue. Directing cell activities to efficiently heal wounds while minimizing the development of scarExpand
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