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Anticancer therapeutic potential of soy isoflavone, genistein.
TLDR
Althoughgenistein has many potentially therapeutic actions against cancer, its biphasic bioactivity requires caution in determining therapeutic doses of genistein alone or in combination with chemotherapy, radiation therapy, and/or immunotherapies. Expand
Antinociceptive effect of certain dihydroxy flavones in mice
TLDR
All the four investigated dihydroxy flavones produced dose related antinociception through mechanisms that involve an interaction with opioid and GABAergic pathways. Expand
Antinociceptive pattern of flavone and its mechanism as tested by formalin assay.
TLDR
Role for opioid system in this action has been demonstrated and formalin test can also be considered as an useful assay procedure for testing flavonoids, however, this assay procedure also has the limitation that it is unable to detect minor changes in the degree of antinociception produced by physiological interventions such as long swim and dextrose. Expand
Involvement of calcium in flavonoid analgesia.
TLDR
Calcium antagonised the analgesic action of flavonoids while nifedipine, a calcium channel blocker, potentiated it, suggesting a possible role for calcium in the analgesics action of Flavonoids as with that of morphine. Expand
Anti-inflammatory effect of certain dihydroxy flavones and the mechanisms involved.
TLDR
The anti-inflammatory effect of dihydroxy flavones may be through mechanisms that involve an interaction with cyclooxygenases, cytokines and reactive oxygen species. Expand
Antinociceptive activity of certain dihydroxy flavones
TLDR
All the investigated dihydroxy flavones exhibited opioid mediated antinociceptive response in mice, and naloxone almost completely antagonized the ant inociception response of the four-dihydroxy flavone compounds. Expand
Role of ATP sensitive potassium channel on 7-hydroxy flavone induced antinociception and possible association with changes in glycaemic status.
TLDR
The present finding suggest that 7-HF induces antinociception like morphine, utilise ATP sensitive potassium channel at the cellular level and do not suggest a cause-effect relationship between the changes in the glycaemic and algesic state. Expand
Anti-nociceptive effect of synthesized di-hydroxy flavones: possible mechanism.
TLDR
It is suggested that these newly synthesized DHFs can be included along with other flavonoids while attempting clinical trial for analgesic use, since poly substituted ones are expected to produce more potent effect. Expand
Analgesic activity of certain flavone derivatives: a structure-activity study.
TLDR
A definite structure-activity relationship was observed in the analgesic activity of flavone derivatives as well as in their mechanism of action. Expand
Gossypin-induced analgesia in mice.
TLDR
A flavonoid, gossypin, was evaluated for its analgesic action by using acetic acid-induced writhing in mice and was compared with morphine and naloxone suggesting a definite involvement of opiate receptors in the analgesicaction of gOSSypin. Expand
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