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Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia
After neuronal injury and in several neurodegenerative diseases, activated microglia secrete proinflammatory molecules that can contribute to the progressive neural damage. The recent demonstrationExpand
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Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans.
This study was undertaken to evaluate, in humans, the antioxidant activity of olive oil phenolics, namely hydroxytyrosol and oleuropein aglycone that share an orthodiphenolic (catecholic) structure.Expand
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Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione.
Matrix metalloproteinase-2 (MMP-2) has emerged as a key protease in various pathologies associated with oxidative stress, including myocardial ischemia-reperfusion, heart failure or inflammation.Expand
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Olive Phenol Hydroxytyrosol Prevents Passive Smoking–Induced Oxidative Stress
BackgroundOxidative stress is involved in the onset of several degenerative disorders, and epidemiological studies indicate that a high intake of dietary antioxidants, as in the case of theExpand
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Cysteinyl‐leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes
We studied the effect of intravascular activation of human neutrophils on the synthesis of cysteinyl leukotrienes (cysLT) and the formation of cerebral edema in guinea‐pig brains. Challenge with theExpand
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Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent.
Cysteine-containing leukotrienes (cysteinyl-LTs) are potent bronchoconstrictors and play a key role in asthma. We found that histamine and LTD4 markedly constrict strips of human bronchi (HB) withExpand
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The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver.
Liver ischemia-reperfusion injury is characterized by cell necrosis and apoptosis and by profound modifications in the extracellular matrix (ECM). During the complex series of events that take placeExpand
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Cyclooxygenase-inhibiting nitric oxide donators for osteoarthritis.
Nonsteroidal anti-inflammatory drugs (NSAIDs) remain the most commonly used medications for the treatment of the symptoms of many chronic inflammatory diseases, including osteoarthritis.Expand
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The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines.
Pro-inflammatory cytokines have been shown to depress myocardial mechanical function by enhancing peroxynitrite generation in the heart. The contribution of NO synthesized by different NOS isoforms,Expand
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