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Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia
TLDR
It is shown that estrogen exerts an anti-inflammatory activity on primary cultures of rat microglia, as suggested by the blockage of the phenotypic conversion associated with activation and by the prevention of lipopolysaccharide-induced production of inflammatory mediators.
Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans.
TLDR
The administration of oil samples with increasing amounts of orthodiphenolic compounds, namely hydroxytyrosol and oleuropein aglycone, results in a dose-dependent reduction in the urinary excretion of 8-iso-PGF(2alpha), and a statistically significant negative correlation between homovanillyl alcohol and HValc urinary concentrations suggests that this metabolite better reflects the in vivo activities of hydroxyTYrosol.
Olive Phenol Hydroxytyrosol Prevents Passive Smoking–Induced Oxidative Stress
TLDR
A low dose of hydroxytyrosol, administered through OMWW, reduces the consequences of sidestream smoke–induced oxidative stress in rats.
The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat
TLDR
Control ischemic rats showed distinct morphological alterations with necrosis of neurons, glial cells and blood vessels, surrounded by a halo with pyknotic cells with cytoplasm swelling and vacuolization, suggesting that selective inhibitors of COX-2 are neuroprotective.
Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione.
TLDR
Mass spectrometry revealed that ONOO(-) can oxidize and, in the presence of GSH, S-glutathiolate the MMP-2 zymogen or a synthetic peptide containing the cysteine-switch motif in the enzyme's autoinhibitory domain, which may be relevant to pathophysiological conditions associated with increased oxidative stress.
Cysteinyl‐leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes
TLDR
The hypothesis that neutrophil and endothelial cells cooperate toward the local synthesis of cysLT within the brain vasculature and, acting via the cys LT2 receptor on endothelial Cells, may represent a contributing pathogenic mechanism in the development of cerebral inflammation and edema is supported.
The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver.
TLDR
This review summarizes current knowledge of MMP biology, with particular attention to the most recent evidence of novel, non-extracellular matrix MMP substrates involved in inflammation and cell cycle regulation.
Cyclooxygenase-inhibiting nitric oxide donators for osteoarthritis.
TLDR
A new class of anti-inflammatory drugs, COX-inhibiting nitric oxide donators (CINODs), has been designed to exert similar anti- inflammatory effects as NSAIDs, but with an improved safety profile.
Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent.
TLDR
In human airways, a novel LTD4 transduction mechanism linked to bronchial smooth-muscle contraction is identified, which is partly independent of Ca2+ and involves the activation of PKC-alpha.
The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines.
TLDR
Although genetic disruption of the iN OS gene provides partial protection against cytokine-induced cardiac dysfunction, iNOS-independent mechanisms, including contribution of NO from other NOS enzymes and the generation of superoxide, are also important contributors.
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