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Cholinergic innervation and function in the prostate gland.
The mammalian prostate is densely innervated by hypogastric and pelvic nerves that play an important role in regulating the growth and function of the gland. While there has been much interest in theExpand
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The α1A‐adrenoceptor gene is required for the α1L‐adrenoceptor‐mediated response in isolated preparations of the mouse prostate
This study investigated whether deletion of the α1A‐adrenoceptor gene influences contractile responses of mouse prostate to noradrenaline. Responses of mouse prostate to noradrenaline are known to beExpand
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The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies.
1. We review literature demonstrating (a) the presence and (b) the actions of substances that mediate or modify neuroeffector transmission to the smooth muscle of the prostrate stroma of a number ofExpand
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John Ludbrook APPS Symposium Neural Mechanisms In The Cardiovascular Responses To Acute Central Hypovolaemia
1. The haemodynamic response to acute central hypovolaemia consists of two phases. During phase I, arterial pressure is well maintained in the face of falling cardiac output (CO) byExpand
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Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH)
Benign prostatic hyperplasia (BPH) is the major cause of lower urinary tract symptoms in men aged 50 or older. Symptoms are not normally life threatening, but often drastically affect the quality ofExpand
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Role of vagal afferents in the haemodynamic response to acute central hypovolaemia in unanaesthetized rabbits.
In unanaesthetized mammals, including rabbits, the response to acute central hypovolaemia is biphasic. An initial phase of baroreflex-mediated systemic vasoconstriction is succeeded by an abruptExpand
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Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (mangrove catsnake).
In this study, we have pharmacologically characterised boigatoxin-A, a three finger toxin isolated from the venom of the colubrid, Boiga dendrophila (Mangrove catsnake). In the chick biventerExpand
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Pharmacology of neurotransmission to the smooth muscle of the rat and the guinea-pig prostate glands.
Histochemical studies carried out on sections of rat and guinea-pig prostate glands revealed the presence of acetylcholinesterase- and noradrenaline-containing nerve fibres in the fibromuscularExpand
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Calcitonin gene-related peptide (CGRP) inhibits contractions of the prostatic stroma of the rat but not the guinea-pig
This study investigated the presence and effects of calcitonin gene-related peptide (CGRP) within the rat and guinea-pig prostate glands. Immunohistochemical studies demonstrated that CGRPExpand
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Adenosine 5'-triphosphate and noradrenaline are excitatory cotransmitters to the fibromuscular stroma of the guinea pig prostate gland.
Immunohistochemical studies demonstrated abundant P2X(1)-receptor immunoreactivity colocalized with alpha-actin within the fibromuscular stroma of the guinea pig prostate. P2X(2)-, P2X(3)- andExpand
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