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The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies.
Taking together the current literature indicates that, in addition to noradrenaline, other neurotransmitters and neuromodulators may regulate the tone of prostatic smooth muscle.
The α1A‐adrenoceptor gene is required for the α1L‐adrenoceptor‐mediated response in isolated preparations of the mouse prostate
This study investigated whether deletion of the α1A‐adrenoceptor gene influences contractile responses of mouse prostate to noradrenaline. Responses of mouse prostate to noradrenaline are known to be
John Ludbrook APPS Symposium Neural Mechanisms In The Cardiovascular Responses To Acute Central Hypovolaemia
1. The haemodynamic response to acute central hypovolaemia consists of two phases. During phase I, arterial pressure is well maintained in the face of falling cardiac output (CO) by
Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH)
It is concluded that recent basic research has revealed a number of novel drug targets such as muscarinic receptor or P2X‐purinoceptor antagonists, which have the potential to produce more effective and safer drug treatments.
Pharmacology of neurotransmission to the smooth muscle of the rat and the guinea-pig prostate glands.
Histochemical studies carried out on sections of rat and guinea-pig prostate glands revealed the presence of acetylcholinesterase- and Noradrenaline-containing nerve fibres in the fibromuscular stroma, indicating that neurotransmission to the prostatic smooth muscle in both species is predominantly sympathetic and noradrenergic, and that norad Renaline released during field stimulation acts at postjunctional alpha1-adrenoceptors.
Sympathetic co‐transmission to the cauda epididymis of the rat: characterization of postjunctional adrenoceptors and purinoceptors
It is concluded that both ATP and noradrenaline may act as co‐transmitters in the sympathetic nerves supplying the smooth muscle of the rat cauda epididymis, and that α1‐adrenoceptors and P2X‐purinoceptors are present postjunctionally.