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Odds ratios for mediation analysis for a dichotomous outcome.
For dichotomous outcomes, the authors discuss when the standard approaches to mediation analysis used in epidemiology and the social sciences are valid, and they provide alternative mediation…
Conceptual issues concerning mediation, interventions and composition
Concepts concerning mediation in the causal inference literature are reviewed. Notions of direct and indirect effects from a counterfactual approach to mediation are compared with those arising from…
Mediation Analysis with Multiple Mediators
Two analytic approaches, one based on regression and onebased on weighting are proposed to estimate the effect mediated through multiple mediators and the effects through other pathways, which are robust to unmeasured common causes of two or more mediators.
A simple unified approach for estimating natural direct and indirect effects.
- T. Lange, S. Vansteelandt, Maarten Bekaert
- Computer ScienceAmerican Journal of Epidemiology
- 1 August 2012
A simple procedure based on marginal structural models that directly parameterize the natural direct and indirect effects of interest is introduced and has the advantage that it can be conducted in standard software.
Causal inference with generalized structural mean models
Summary. We estimate cause–effect relationships in empirical research where exposures are not completely controlled, as in observational studies or with patient non‐compliance and self‐selected…
Effect decomposition in the presence of an exposure-induced mediator-outcome confounder.
Three alternative approaches to effect decomposition are described that give quantities that can be interpreted as direct and indirect effects and thatCan shed insight into pathways and questions of mediation even when an exposure-induced mediator-outcome confounder is present.
Ignorance and uncertainty regions as inferential tools in a sensitivity analysis
A definition of consistency for a region is proposed and the concepts of pointwise, weak and strong coverage for larger regions which acknowledge sampling imprecision in addition to the structural lack of information are introduced.
Causal Mediation Analysis with Multiple Mediators
This article aims to bridge the gap from “single mediator theory” to “multiple mediator practice,” highlighting the ambitious nature of this endeavor and giving practical suggestions on how to proceed, and discussing the strong assumptions under which the effects are identified.
Regression Models for Disease Prevalence with Diagnostic Tests on Pools of Serum Samples
Joint pool and sample size calculations using information from individual contributors to the pool are performed and it is shown that a good design can severely reduce cost and yet increase precision.
Distribution of Human Papillomavirus in a Family Planning Population in Nairobi, Kenya
The pattern of HPV distribution in this population was different from that in other regions in the world, which has important consequences for HPV vaccine development.