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Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
The authors' results confirmed previously reported data in the literature concerning isoforms expression in the most currently studied tissues and provided a great deal of new information, mainly about the expression of mRNA of little-known CYP isoforms.
PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
PIK3CA mutation is an emerging tumor marker which might become used in treatment-choosing process and should be now confirmed in larger series of patients included in randomized prospective ERBB2-positive breast cancer patients.
Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach.
Surprisingly, only a small proportion of the 51 genes identified in breast tumor biopsy specimens were confirmed to be ERalpha-regulated and/or E2-regulated in vitro (cultured cell lines) and better delineate the role of ERalpha in breast cancer.
Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity.
The findings suggest the utility for the DNA methylation patterns in these genes as clinically useful surrogate markers in breast cancer, as well as new molecular pathways for further investigation as therapeutic targets, are suggested.
Inhibitory signalling to the Arp2/3 complex steers cell migration
A new protein is identified, Arpin, that inhibits the Arp2/3 complex in vitro, and it is shown that Rac signalling recruits and activates Arpin at the lamellipodial tip, like WAVE.
microRNA expression profile in a large series of bladder tumors: Identification of a 3‐miRNA signature associated with aggressiveness of muscle‐invasive bladder cancer
A 3‐miRNA signature was found to be related to MIBC tumor aggressiveness and was associated with both recurrence‐free and overall survival in univariate analysis with a trend to significance in the multivariate analysis.
CXC chemokines located in the 4q21 region are up-regulated in breast cancer.
It is presented evidences that multiple CXC chemokines are co-expressed in CXCL8-positive breast tumors and could account for the higher aggressiveness of these types of tumors.
PIK3R1 underexpression is an independent prognostic marker in breast cancer
PIK3CA mutations and PIK3R1 underexpression show opposite effects on patient outcome and could become useful prognostic and predictive factors in breast cancer.
High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors.
The contradictory observation of putative metastasis inhibitor role of kisspeptins and RFS to TAM treatment suggests that evaluation of KiSS1 and its receptor tumoral mRNA levels could be new interesting markers of the tumoral resistance to anti-estrogen treatment.
NF-kappa B genes have a major role in Inflammatory Breast Cancer
The NF-κB pathway appears to play a major role in IBC, possibly contributing to the unusual phenotype and aggressiveness of this form of breast cancer.