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Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats
The present results imply that ROS generated from the glycation reaction of increased glucose levels caused by gluconeogenesis activation through glucocorticoid with proteins in the serum attack the hippocampus to induce neurodegeneration, resulting in cognitive deficits in rats. Expand
Antioxidant activity of eugenol and related monomeric and dimeric compounds.
Electron spin resonance (ESR) spin trapping experiments revealed that eugenol and its dimer, having allyl groups in the structure, scavenged superoxide, and that only eugenoli trapped hydroxyl radicals under the conditions used, suggesting that e Eugenol and dieugenol have a different mechanism of antioxidation, i.e. eugenolin may inhibit lipid peroxidation at the level of initiation. Expand
Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers.
The oxidative hemolysis of rabbit erythrocytes induced by free radicals and its inhibition by chain-breaking antioxidants have been studied and chain- Breaking antioxidants incorporated into the liposomes were also effective in suppressing this hemolyses. Expand
Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems
Although the memory functions of all rats were impaired after oxidative stress, the memory retention of young rats was greater than those of other groups, suggesting that oxidative stress may contribute to learning and memory deficits following oxidative brain damage during aging. Expand
Cognitive Impairment of Rats Caused by Oxidative Stress and Aging, and Its Prevention by Vitamin E
Results suggest that oxidative damage to the rat synapse in the cerebral cortex and hippocampus during aging may contribute to the deficit of cognitive functions. Expand
Antioxidant activity of Magnolol, honokiol, and related phenolic compounds
The antioxidant activity of 10 Japanese and Chinese crude drugs (Kampo drugs) was determined in vitro. Extract of Magnolia cortex, which had the highest antioxidant activity, contained phenolicExpand
Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism.
Hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer rather than via electron transfer, the rate constant of which is comparable to that ofExpand
Oxidative injury of synapse and alteration of antioxidative defense systems in rats, and its prevention by vitamin E.
The results suggest that free radicals derived from oxygen may attack nerve terminals and peroxidize the plasma membrane, and support the idea that vitamin E contributes to the protection against nerve dysfunction caused by oxidative stress. Expand
Mobility and molecular orientation of vitamin E in liposomal membranes as determined by 19F NMR and fluorescence polarization techniques.
Results show that when praseodymium ions may pass through the liposomal membrane, the hydrogen bonds between alpha-tocopherol and the ester carbonyl of PC may be broken, leading to the formation of an alpha-ocopherol-Pr3+ complex, thus causing the fluidity to increase. Expand
Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II).
The results show that the 4-hydroxystilbene structure of 1 is a major determinant of generation of reactive oxygen species that was responsible for DNA strand scission. Expand