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Ohmyungsamycins A and B: cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island.
  • S. Um, T. J. Choi, +6 authors D. Oh
  • Chemistry, Medicine
  • The Journal of organic chemistry
  • 26 November 2013
TLDR
A new method utilizing PGME (phenylglycine methyl ester) derivatization coupled with chromatographic analysis to determine the absolute configuration of N,N-dimethylvaline is developed, which will provide a general and convenient analytical method for determining the absolute configurations of amino acids with fully substituted amine groups. Expand
Sungsanpin, a lasso peptide from a deep-sea streptomycete.
TLDR
Sungsanpin is the first example of a lasso peptide isolated from a marine-derived microorganism and displayed inhibitory activity in a cell invasion assay with the human lung cancer cell line A549. Expand
The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi
TLDR
It is suggested that this lineage of antibiotic-producing Bacillus may be a defensive symbiont involved in the protection of the fungus-growing termite cultivar. Expand
Thalassospiramide G, a New γ-Amino-Acid-Bearing Peptide from the Marine Bacterium Thalassospira sp
TLDR
Thalassospiramides A and D inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells, with IC50 values of 16.4 and 4.8 μM, respectively. Expand
Mitochondria and DNA Targeting of 5,10,15,20-Tetrakis(7-sulfonatobenzo[b]thiophene) Porphyrin-Induced Photodynamic Therapy via Intrinsic and Extrinsic Apoptotic Cell Death.
TLDR
SBTP demonstrated effective PDT activity of 5 μM IC50 value to MCF-7 cells by bitargeting mitochondria and DNA by bit targeting the intrinsic apoptotic pathway. Expand
Naphthoquinone-Oxindole Alkaloids, Coprisidins A and B, from a Gut-Associated Bacterium in the Dung Beetle, Copris tripartitus.
Coprisidins A and B (1 and 2) were isolated from a gut-associated Streptomyces sp. in the dung beetle Copris tripartitus. Using a combination of spectroscopic techniques, the structures of theExpand
Coprisamides A and B, new branched cyclic peptides from a gut bacterium of the dung beetle Copris tripartitus.
TLDR
Spectroscopic analysis revealed that the planar structures of 1 and 2 are novel cyclic heptapeptides bearing unusual units, such as β-methylaspartic acid and 2,3-diaminopropanoic acid branched to valine and 2-heptatrienyl cinnamic acid. Expand
Coculture of Marine Streptomyces sp. With Bacillus sp. Produces a New Piperazic Acid-Bearing Cyclic Peptide
TLDR
Dentigerumycin E exhibited antiproliferative and antimetastatic activities against human cancer cells, indicating that N-OH and carboxylic acid functional groups are essential for the biological activity. Expand
Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway
TLDR
Data show that OMS is a promising candidate for new anti-mycobacterial therapeutics by activating antibacterial autophagy via AMPK-dependent signaling and suppressing excessive inflammation during Mtb infections. Expand
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