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Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.
TLDR
The results suggest that ASICs are leading acid sensors in human nociceptors and that VR1 participates in the nocICEption mainly under extremely acidic conditions.
Functional Interaction between T2R Taste Receptors and G-Protein α Subunits Expressed in Taste Receptor Cells
TLDR
A heterologous expression system is used to determine a specific domain of gustducin necessary for T2R coupling and expresses G16 protein chimeras with the corresponding domain from other Gαi proteins, cone-transducin (Gαt2, G αi2, and Gαz), which could be useful tools to analyze the functions of many orphan G-protein-coupled taste receptors.
Receptor that leaves a sour taste in the mouth
TLDR
A complementary DNA is identified that encodes a receptor for sour tastes in taste-bud cells and is identified as G proteins, a type of guanine-nucleotide-binding proteins found in G proteins.
P2X2‐ and P2X3‐positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and mice
TLDR
Findings suggest that most P 2X2 and P2X3 receptors in fungiform papillae are used for gustation rather than somatosensation.
TRPM8 activation suppresses cellular viability in human melanoma.
TLDR
The results reveal that a functional TRPM8 protein is expressed in human melanoma cells to involve the mechanism underlying tumor progression via the Ca(2+) handling pathway, providing us with a novel target of drug development for malignant melanoma.
Differential Localizations of the Transient Receptor Potential Channels TRPV4 and TRPV1 in the Mouse Urinary Bladder
TLDR
Findings raise the possibility that, in mouse urothelial cells, TRPV4 may contribute to the detection of increases in intravesical pressure related to the micturition reflex.
Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae.
TLDR
Findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature.
Protons Activate the δ-Subunit of the Epithelial Na+ Channel in Humans*
TLDR
Human ENaCδ activity is regulated by protons, indicating that it may contribute to the pH sensation and/or pH regulation in the human brain.
In situ hybridization evidence for the coexistence of ASIC and TRPV1 within rat single sensory neurons.
TLDR
Histological relations among ASIC clones and the colocalization of each ASIC subunit and TRPV1 within single sensory neurons were examined on serial sections of rat dorsal root ganglia (DRG) using in situ hybridization histochemistry.
Amiloride-Insensitive Currents of the Acid-Sensing Ion Channel-2a (ASIC2a)/ASIC2b Heteromeric Sour-Taste Receptor Channel
TLDR
Oocyte electrophysiology demonstrated that the ASIC2a/ASIC2b channel generated maximal inward currents at a pH of ≤2.0, which is in agreement with the in vivo pH sensitivity of rat taste cells, and that the amiloride sensitivity of the heteromer decreased with decreasing pH and was almost completely abolished atA pH of 2.0.
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