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Mechanical Allodynia Caused by Intraplantar Injection of P2X Receptor Agonist in Rats: Involvement of Heteromeric P2X2/3 Receptor Signaling in Capsaicin-Insensitive Primary Afferent Neurons
Extracellular ATP has been known to activate sensory neurons via the ATP-gated ion channels P2X receptors, indicating that the P2X receptors may play a role in signal transduction of pain from theExpand
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Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice
The aim of the present study is to characterize the role of spinal endogenous ATP and P2X receptors in the generation of neurogenic and inflammatory pain. We examined the effects of intrathecalExpand
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Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
Alcohols in the homologous series of n-alcohols increase in central nervous system depressant potency with increasing chain length until a "cutoff" is reached, after which further increases inExpand
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In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system.
1. The aim of the present study is to characterize the role of the P2X receptor in spinal nociceptive processing in vivo. We investigated the mechanisms of the P2X receptor agonistExpand
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Subunit mutations affect ethanol actions on GABAA receptors expressed in Xenopus oocytes
Mutations of specific amino acids were introduced in transmembrane domains (TM) of GABAA receptor α2, β1 and γ2L subunits. The effects of these mutations on the action of ethanol were studied usingExpand
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Tryptophan scanning mutagenesis in TM2 of the GABAA receptor α subunit: effects on channel gating and regulation by ethanol
Each residue in the second transmembrane segment (TM2) of the human GABAA receptor α2 subunit was individually mutated to tryptophan. The wild‐type or mutant α2 subunits were expressed with theExpand
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Kinetic properties of T-type Ca2+ currents in isolated rat hippocampal CA1 pyramidal neurons.
1. T-type Ca2+ channels producing a transient inward current were studied in pyramidal neurons acutely isolated from the ventral portion of rat hippocampal CA1 region. Membrane currents were recordedExpand
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Behavioral response of sharks to electric stimulation
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Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.
UNLABELLED Previous work demonstrates that various anesthetics enhance the effect of gamma-aminobutyric acid (GABA), and this enhancement has been proposed as an explanation for how anesthetics causeExpand
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Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus.
1. The intracellular mechanisms of serotonin (5-HT) response were investigated in dissociated rat hippocampal pyramidal neurons using the nystatin-perforated patch technique. 2. Under voltage-clampExpand
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