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Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients – A Bioinformatics Approach
TLDR
Four genes (EGR1, CD38, CAV1, and AKT1) were identified to be strongly associated with SLE and might serve as potential biomarkers in early diagnosis and as therapeutic targets for SLE. Expand
PSO-based feature selection and neighborhood rough set-based classification for BCI multiclass motor imagery task
In recent years, most of the researchers are developing brain–computer interface (BCI) applications for the physically disabled to be able to interconnect with peripheral devices based on brainExpand
Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach
TLDR
This study identified seven core genes (UQCR11, UBE2N, ADD1, TLN1, IRAK3, LY96, and MAP3K1) that are strongly linked to FH and lead to a higher risk of atherosclerosis. Expand
EOG based wheelchair control for quadriplegics
TLDR
The eye movement can be considered as a significant communication tool for tetraplegia and it has been proposed to control the wheelchair of physically handicapped people with their eye movements. Expand
Mutations in ARSB in MPS VI patients in India
TLDR
Eight out of nine mutations in ARSB found in Indian MPS VI patients have been found only in India, which suggests that the population studied by the study might have its own typical set of mutations, with other populations equally likely to have their ownSet of mutations. Expand
Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach
TLDR
Two compounds exhibited the highest binding affinity with the selected mutants and were chosen for further analysis, which are expected to aid in the field of precision medicine and further to in vivo and in vitro analysis of these lead compounds might shed light on the treatment of PMM2-CDG. Expand
Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by bioinformatics approach.
TLDR
This study yielded a significant role of glycosaminoglycan binding, endothelin, and GABA-B receptor signaling pathway in IPF pathogenesis, and the enrichment pathway analysis suggests that most of the pathways were corresponding to membrane transport and signal transduction functionalities. Expand
Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.
TLDR
The computational pipeline provided in this study helps to elucidate the potential structural and functional differences between the ALDH3A2 native and mutant homodimeric proteins, and will pave the way for drug discovery against specific targets in the SLS patients. Expand
Isolation, characterization, and in vitro evaluation of bovine rumen submucosa films of collagen or chitosan-treated collagen
TLDR
The results of cell viability and proliferation demonstrated that COL-F and COL/CS-F exhibit good biocompatibility and therefore can augment cell infiltration and proliferation. Expand
Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome.
TLDR
This study tried to identify all the reported mutations in the NOD2 protein that cause BS and found the W490L mutation is positioned in the ADP binding site and exhibits highly deleterious and destabilizing properties, expected to serve as a platform for developing targeted drug therapy for BS. Expand
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