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Recommendations for the management of herpes zoster.
The results of controlled trials and the clinical experience of the authors support the use of acyclovir, brivudin (where available), famciclovir, and valacy Clovir as first-line antiviral therapy for the treatment of patients with HZ.
High-Level Variability in the ORF-K1 Membrane Protein Gene at the Left End of the Kaposi’s Sarcoma-Associated Herpesvirus Genome Defines Four Major Virus Subtypes and Multiple Variants or Clades in…
Overall, it is suggested that rather than being a newly acquired human pathogen, HHV8 is an ancient human virus that is preferentially transmitted in a familial fashion and is difficult to transmit horizontally in the absence of immunosuppression.
Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A.
There are statistically significant differences in the frequency of the polymorphic mutations in the MTHFR gene C677T, C1298A, and newly discovered mutation G1793A, as well as the association with MTRR polymorphic site A66G in different ethnic groups.
Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review.
- E. Chiao, T. Giordano, J. Palefsky, S. Tyring, Hashem B El Serag
- MedicineClinical Infectious Diseases
- 15 July 2006
A systematic review of the indirect evidence regarding the utility of anal Papanicolau (Pap) smear screening of HIV-infected individuals in the highly active antiretroviral therapy era identifies important areas for further study before routine anal Pap smear screening can be recommended.
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.
- H. Erlandsen, A. Pey, R. Stevens
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 30 November 2004
The biochemical and kinetic characterization of the 15 mutants studied points toward a multifactorial basis for the BH4 responsiveness; the mutants show residual activity (>30% of WT) and display various kinetic defects, including increased Km (BH4) and reduced cooperativity of substrate binding, but no decoupling of cofactor (Bh4) oxidation.
Long-term safety and efficacy of 50 mg of etanercept twice weekly in patients with psoriasis.
Extended exposure to 50 mg of etanercept twice weekly resulted in exposure-adjusted rates of adverse events and infections similar to those in patients receiving placebo, and improvements in physician- and patient-reported measures of psoriasis severity were observed for up to 96 weeks of continuous etanerscept therapy.
The final author version and the galley proof are versions of the publication after peer review that features the final layout of the paper including the volume, issue and page numbers.
p53 mutations in basal cell carcinomas.
The hypothesis that UV may act on the p53 gene in a carcinogenic-specific fashion is suggested by the striking similarity of the type of mutations detected in this study and with the UV mutagenesis studies reported in literature.
Knock‐out mouse for Canavan disease: a model for gene transfer to the central nervous system
The successful creation of a knock‐out mouse for Canavan disease that can be used for gene transfer and the lack of an animal model has been a limiting factor in developing vectors for the treatment of CD.
Viral and Nonviral Uses of Imiquimod: A Review
- Aditya K. Gupta, Andréa M Cherman, S. Tyring
- MedicineJournal of cutaneous medicine and surgery
- 1 September 2004
This review examines the role of imiquimod 5% cream in the treatment of skin diseases such as actinic keratoses, basal cell carcinoma, Bowen’s disease, lentigo maligna, and extramammary Paget's disease and demonstrates indirect antiviral and antitumor effects.