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The enhancement of gene silencing efficiency with chitosan-coated liposome formulations of siRNAs targeting HIF-1α and VEGF.
- E. Salva, S. Turan, F. Eren, J. Akbuǧa
- Biology, Medicine
- International journal of pharmaceutics
- 15 January 2015
Results show that the chitosan coating process is an effective parameter for particle size and the zeta potential of liposomes, and the co-delivery of siHIF1-α and siVEGF was greatly enhanced in the vitro gene silencing efficiency. Expand
Chemical Delay: An Alternative to Surgical Delay Experimental Study
The authors demonstrate the usefulness of a novel chemical delay technique that obviates the need for a surgical delay procedure and lends further support to the role of relative hypoxia as the primary promoter of the delay phenomenon. Expand
Inhibition of Glomerular Mesangial Cell Proliferation by siPDGF-B- and siPDGFR-β-Containing Chitosan Nanoplexes
Gene silencing approaches with chitosan-based gene delivery systems have promise for the efficient treatment of renal disease and suggested that mesangial cell proliferation may be inhibited by silencing of the PDGF-B signaling pathway. Expand
Investigation of the therapeutic efficacy of codelivery of psiRNA-vascular endothelial growth factor and pIL-4 into chitosan nanoparticles in the breast tumor model.
- E. Salva, S. Turan, +4 authors J. Akbuǧa
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 March 2014
Results indicate that chitosan NPs can be effectively used for the codelivery of pIL-4 and siVEGF-expressing plasmid in a combination therapy against breast cancer. Expand
The development of ternary nanoplexes for efficient small interfering RNA delivery.
Ternary nanoplexes have the potential to be an effective siRNA carrier to study the gene silencing effect and Serum stability and the lack of cytotoxicity of the nanoplex provided advantages over other gene silenced studies. Expand
Non-viral siRNA and shRNA Delivery Systems in Cancer Therapy
This chapter highlights the importance of non-viral delivery systems in vitro and in vivo cancer therapy and development of appropriate delivery systems is an important issue in the use of siRNA-based therapeutics. Expand
In vitro PDGF-B gene silencing studies and In vivo delivery of siRNA to the rat kidney using Chitosan/siRNA nanoplexes
Results suggest that delivery of siRNA using chitosan nanoplexes may be effective for the therapy of kidney diseases. Expand
Synthesis and evaluation of cytotoxic activities of some substituted isoxazolone derivatives
Several isoxazolone derivatives were synthesized, starting from substituted 1,3,4-thiadiazoles and 1,2,4-triazole-3-thione. In the first part of the research, compounds… Expand
In vitro gene silencing effect of chitosan/shRNA PDGF-D nanoparticles in breast cancer
Breast cancer is the most common cancer worldwide in women and it is highly malignant and fatal. PDGF-D plays role in regulation of many cellular processes such as angiogenesis. PDGF-D is… Expand
Spectrophotometric, voltammetric and cytotoxicity studies of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives: a combined experimental-computational study.
- E. G. Akgemci, A. O. Saf, +4 authors M. Akkiprik
- Chemistry, Medicine
- Spectrochimica acta. Part A, Molecular and…
- 5 February 2015
In this study, 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) and its novel N(4) substituted derivatives were synthesized and characterized by different techniques and exhibit that all compounds have good electron-donor properties which affect anti-proliferative activity. Expand