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Rat CINC, a member of the interleukin-8 family, is a neutrophil-specific chemoattractant in vivo.
Rat cytokine-induced neutrophil chemoattractant (CINC) is a member of the IL-8 family and its human counterpart is MGSA/gro. Rat neutrophil responses in vitro to rat CINC, human IL-8, and humanExpand
Characterization of rat LECAM‐1 (L‐selectin) by the use of monoclonal antibodies and evidence for the presence of soluble LECAM‐1 in rat sera
We have characterized the rat LECAM‐1 (L‐selectin) by the use of newly generated hamster anti‐rat LECAM‐1 monoclonal antibodies (mAb) (HRL1, HRL2, HRL3, HRL4), with respect to the biochemistry,Expand
The role of glucocorticoid receptor and gene expression in the anti-inflammatory action of dexamethasone
GLUCOCORTICOIDS are potent anti-inflammatory agents, but the molecular mechanisms involved in this activity are not yet understood. The biological actions of various steroid hormones have been shownExpand
Glucocorticoid-mediated Gene Suppression of Rat Cytokine-induced Neutrophil Chemoattractant CINC/gro, a Member of the Interleukin-8 Family, through Impairment of NF-B Activation (*)
The glucocorticoid dexamethasone inhibited the production of the rat cytokine-induced neutrophil chemoattractant CINC/gro, a counterpart of human melanoma growth-stimulating activity that belongs toExpand
Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections.
The mechanism for neutrophil (PMN) influx into infected airspaces of the lung is not known. To determine whether alveolar macrophage products are important in the initiation of chemotaxis, weExpand
Antiinflammatory actions of ephedrines in acute inflammations.
Ephedrine (EP), pseudoephedrine (PEP), ephedroxane (EX) and pseudoephedroxane (PEX) inhibited carrageenin-induced hind-paw edema in sham-operated mice as well as adrenalectomized mice. Hind-paw edemaExpand
Level of neutrophil chemotactic factor CINC/gro, a member of the interleukin-8 family, associated with lipopolysaccharide-induced inflammation in rats.
Rat cytokine-induced neutrophil chemoattractant (CINC), which is a counterpart of human gro and belongs to the interleukin-8 family, has been quantified by a new sandwich enzyme-linked immunosorbentExpand
Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages
1 At concentrations above 10 ng ml−1, the tumour promoter thapsigargin stimulates the release of radioactivity from [3H]‐arachidonic acid‐labelled macrophages harvested from rat peritoneal cavity. 2Expand
Kupffer cell production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion injury in rats.
We investigated the role of hepatic macrophages in the inflammatory response following reperfusion injury by blocking Kupffer cell phagocytosis with gadolinium chloride (GdCl3). Liver ischemia wasExpand
Chemoattractants for neutrophils in lipopolysaccharide-induced inflammatory exudate from rats are not interleukin-8 counterparts but gro-gene-product/melanoma-growth-stimulating-activity-related
Potent chemotactic activity for neutrophils was detected in rat inflammatory exudate induced by a subcutaneous injection of lipopolysaccharide in a carboxymethyl-cellulose suspension. We purified andExpand