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Multifunctional strands in tight junctions
TLDR
New insights into the molecular architecture of tight junctions allow us to now discuss the structure and functions of this unique cell–cell adhesion apparatus in molecular terms. Expand
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
TLDR
In claudin-5–deficient mice, the size-selective loosening of the blood-brain barrier was selectively affected, which provides new insight into the basic molecular physiology of BBB and opens a new way to deliver potential drugs across the BBB into the central nervous system. Expand
Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin
TLDR
It is indicated that multiple integral membrane proteins with four putative transmembrane domains, occludin and claudins, constitute TJ strands. Expand
Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association
TLDR
Observations indicate that the Rho-kinase–dependent phosphorylation interferes with the intramolecular and/ or intermolecular head-to-tail association of ERM proteins, which is an important mechanism of regulation of their activity as actin filament/plasma membrane cross-linkers. Expand
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
TLDR
Findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin. Expand
Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins
TLDR
Detailed analyses showed that ZO-2 andZO-3 are recruited to the claudin-based networks through PDZ1 and PDZ2 domains of Z o-1/Zo-2/Z o-3 were also recruited to claudIn-based TJs, when introduced into cultured epithelial cells. Expand
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.
TLDR
Six more claudin-like proteins are reported, indicating the existence of aClaudin gene family, and it is indicated that multipleclaudin family members are involved in the formation of TJ strands in various tissues. Expand
A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts
TLDR
Findings suggested that claudin-1 and -2 are mainly responsible for TJ strand formation, and that occludin is an accessory protein in some function of TJ strands. Expand
ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation
TLDR
ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized, indicating that epithelial cells construct the diffusion barrier allowing them to separate different body compartments. Expand
Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells
TLDR
Findings indicated that claudin-5/TMVCF is an endothelial cell–specific component of TJ strands, which are thought to determine vascular permeability. Expand
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