• Publications
  • Influence
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.
CONTEXT Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department. OBJECTIVE To test the hypothesis ofExpand
  • 817
  • 27
  • PDF
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival.
STUDY OBJECTIVE To study early microcirculatory perfusion indices in patients with severe sepsis/septic shock, compare early microcirculatory indices in sepsis survivors versus nonsurvivors, andExpand
  • 512
  • 20
Emergency department overcrowding in the United States: an emerging threat to patient safety and public health
Numerous reports have questioned the ability of United States emergency departments to handle the increasing demand for emergency services. Emergency department (ED) overcrowding is widespread in USExpand
  • 667
  • 19
  • PDF
Severe sepsis and septic shock: review of the literature and emergency department management guidelines.
Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, andExpand
  • 302
  • 19
  • PDF
Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit*
Objective:Numerous factors can cause delays in transfer to an intensive care unit for critically ill emergency department patients. The impact of delays is unknown. We aimed to determine theExpand
  • 716
  • 17
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.
CONTEXT Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking. OBJECTIVE To testExpand
  • 653
  • 15
  • PDF
MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS
We sought to determine (a) if early lactate clearance is associated with improved survival in emergency department patients with severe sepsis and (b) the concordance between central venous oxygenExpand
  • 325
  • 13
  • PDF
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation*
Objectives:Organ failure worsens outcome in sepsis. The Sequential Organ Failure Assessment (SOFA) score numerically quantifies the number and severity of failed organs. We examined the utility ofExpand
  • 326
  • 13
  • PDF
Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings.
Studies of acute myocardial infarction, trauma, and stroke have been translated into improved outcomes by earlier diagnosis and application of therapy at the most proximal stage of hospitalExpand
  • 291
  • 13
  • PDF