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- Publications
- Influence
Metabolism of guanido-labeled (C-14)arginine in rats, mice, and man.
- C. Frondoza, S. Trivedi, R. Humphrey, J. Goble
- Chemistry, Medicine
- Journal of nuclear medicine : official…
- 1980
[6-14C]arginine, injected intraperitoneally into normal rats, was cleared from the plasma with biphasic decay kinetics. Urinary excretion was efficient (32% of the 25-muCi dose within the first 24… Expand
Effect of cromakalim and pinacidil on 86Rb efflux from guinea pig urinary bladder smooth muscle.
- S. Trivedi, S. Stetz, R. Levin, J. Li, S. Kau
- Chemistry, Medicine
- Pharmacology
- 1 July 1994
86Rb efflux assay was used to investigate the effect of cromakalim, pinacidil and P1075 in guinea pig urinary bladder strips. The type of K channel opened by cromakalim and pinacidil was determined… Expand
STUDIES WITH MURINE LPC‐1 PLASMACYTOMA USING [6‐14C]ARGININE
- R. Humphrey, S. Trivedi, C. Frondoza
- Biology, Medicine
- Cell and tissue kinetics
- 1 January 1979
[6‐14C]Arginine ([6‐14C]Arg) was used as an in vivo pulse label to study BALB/c murine LPC‐1 plasmacytoma synthesis and secretion of its tumour‐associated M component (IgG2a, k). With this isotope,… Expand
K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle.
- S. Trivedi, S. Stetz, +7 authors D. Trainor
- Chemistry, Medicine
- Pharmacology
- 1 June 1995
Zeneca ZD6169, (S)-N-(4-benzoylphenyl)-3,3,3-trifluoro- 2-hydroxy-2-methylpropionamide, is a novel compound which relaxes urinary bladder smooth muscle in vitro. The effect of ZD6169 and two of its… Expand
Calcium dependent K-channels in guinea pig and human urinary bladder.
- S. Trivedi, L. Potter-Lee, +6 authors S. Kau
- Chemistry, Medicine
- Biochemical and biophysical research…
- 15 August 1995
This study provides evidence for the presence of large conductance Ca(2+)-dependent K-channels in guinea pig and human urinary bladder smooth muscle. A23187, a Ca(2+)-ionophore, increased… Expand
Temporary disappearance ("eclipse") of LPC-1 plasmacytoma M component synthesis following tumor cell transfer.
- C. Frondoza, S. Trivedi, R. Humphrey
- Biology, Medicine
- Cancer research
- 1 July 1979
The early phase of LPC-1 plasmacytoma development was studied by in vivo labeling with [6-14C]arginine using its M component (immunoglobulin G 2a,kappa) as marker. At a time when M component was not… Expand
Direct bone resorbing activity of murine myeloma cells.
- D. F. Mcdonald, B. Schofield, +5 authors R. Humphrey
- Chemistry, Medicine
- Cancer letters
- 1 June 1983
The cellular mechanism(s) responsible for tumor-associated bone resorption in multiple myeloma remain uncertain. Both in vivo and in vitro evidence is presented for the direct resorption of bone by… Expand
Development and characterization of a cyclophosphamide-resistant mouse plasmacytoma cell line.
- C. Frondoza, S. Trivedi, R. Humphrey
- Medicine
- Cancer treatment reports
- 1 July 1982
Murine LPC-1 plasmacytoma is sensitive to treatment with cyclophosphamide (CY), and animals bearing this tumor in advanced stages can be cured with doses as small as 60 mg/kg. With repeated transfer… Expand
Hydroxyethyl starch serum levels in leukapheresis donors measured by modified periodic acid‐Schiff staining technique
- S. Trivedi, R. Humphrey, H. Braine, C. Frondoza
- Chemistry, Medicine
- Transfusion
- 6 May 1984
Hydroxyethyl starch (HES), a glucopyranose polymer used to enhance the yield of granulocytes during leukapheresis, was detected by periodic acid‐Schiff (PAS) staining of 1‐microliter samples… Expand
Modified technique for periodic acid-Schiff staining of glycoproteins on agarose-film electrophoretograms.
- S. Trivedi, C. Frondoza, R. Humphrey
- Chemistry, Medicine
- Clinical chemistry
- 1 May 1983
We have modified the periodic acid-Schiff staining technique for glycoproteins for use with thin agarose-film electrophoresis membranes. With this procedure, carbohydrate-rich proteins can be… Expand