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Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration
TLDR
Therapeutic efforts to achieve attenuation of oxidative stress could be beneficial in AD treatment, attenuating Aβ‐induced neurotoxicity and improve neurological outcomes in AD. Expand
Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus
TLDR
This review examines the development of vanadium-containing compounds in biological systems regarding the role of the physiological environment, dosage, intracellular interactions, metabolic transformations, modulation of signaling pathways, toxicology, and transport and tissue distribution as well as therapeutic implications and sheds light on the prevailing gaps between primary scientific data and information from animal models and human studies. Expand
A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats
TLDR
It is demonstrated that HCD (90 day consumption) induces an alteration of the main energy metabolism markers, indicating the development of MS in rats, and the effect of the consumption of a high‐calorie diet on both neurodegeneration and spatial memory impairment in rats is evaluated. Expand
Chronic cadmium exposure in rats produces pancreatic impairment and insulin resistance in multiple peripheral tissues.
TLDR
Changes in Wistar rats likely occur as a consequence of reduced sensitivity and increased insulin resistance in multiple insulin-dependent and non-dependent tissues, producing a biochemical phenotype similar to metabolic syndrome and diabetes. Expand
Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats
TLDR
It is suggested that chronic consumption of alcohol in combination with ED causes an inflammatory response and oxidative stress, which induced cell death via apoptosis in the TCx and Hp of the adult rats. Expand
Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats
TLDR
It is demonstrated that 90days of a high-calorie diet alters the metabolic energy markers causing the MS and causes memory impairments, evaluated by the recognition of novel objects test (NORT). Expand
Changes on serum and hepatic lipidome after a chronic cadmium exposure in Wistar rats.
A mixture of chamomile and star anise has anti-motility and antidiarrheal activities in mice
TLDR
The results indicate that the combination of chamomile and star anise can be used as an alternative antidiarrheal treatment, and indicates that the appearance of diarrhea is delayed and the number of evacuations decreased in comparison with the control group. Expand
Gallic acid improves recognition memory and decreases oxidative‐inflammatory damage in the rat hippocampus with metabolic syndrome
TLDR
GA treatment improves metabolism: reducing the oxidative and inflammatory environment that facilitates the recovery of the neuronal morphology in the hippocampus of rats with MS, suggesting that GA could be used therapeutically in metabolic disorders that cause dementia. Expand
Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus
TLDR
MetfDeca treatment was better than the monotherapies with metformin for DM2 and insulin for DM1 and showed a protective effect on pancreatic beta cells of DM1 rats, suggesting a possible regeneration of these cells, since they recovered their insulin levels. Expand
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