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Colorectal Cancer-Specific Cytochrome P450 2W1: Intracellular Localization, Glycosylation, and Catalytic Activity
TLDR
The study identifies for the first time a cytochrome P450 enzyme with a luminal ER orientation and still retaining catalytic activity and suggests the possibility of using CYP2W1 as a drug target in the treatment of colon cancer using antibodies and/or specific CYP 2W1 activated prodrugs. Expand
CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.
TLDR
These epidemiological data obtained from a large population of CRC patients and controls cannot confirm the previously suggested decreased risk for CRC among carriers of CYP2W1*2. Expand
Colon Cancer–Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
TLDR
A novel approach for treatment of colon cancer that uses a locoregional activation of systemically inactive prodrug by the tumor-specific activator enzyme CYP2W1 is suggested. Expand
Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.
A library of duocarmycin bioprecursors based on the CPI and CBI scaffolds was synthesized and used to probe selective activation by cells expressing CYP1A1 and 2W1, CYPs known to be expressed in highExpand
Clinical profile of a new hormone replacement therapy containing 2 mg 17 beta-estradiol and 10 mg dydrogesterone.
TLDR
The 17beta-estradiol/dydrogesterone combination HRT reduced effectively climacteric symptoms, showed no significant changes in endometrial thickness as determined by transvaginal ultrasonography and provided excellent cycle control. Expand
Cytochrome P450 2W1 (CYP2W1) as a novel drug target in colon cancer therapy
Cytochrome P450 2W1 (CYP2W1), is a monooxygenase enzyme endogenously expressed in fetal colon and normally silenced after birth. In adult life, the expression of CYP2W1 occurs exclusively in tumorExpand
Cancer Therapy : Preclinical Colon Cancer – Speci fi c Cytochrome P 450 2 W 1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
Purpose: Cytochrome P450 2W1 (CYP2W1) is a monooxygenase detected in 30% of colon cancers, whereas its expression in nontransformed adult tissues is absent, rendering it a tumor-specific drug targetExpand
Duocarmycin Analogues into Potent Tumor Cytotoxins Specific Cytochrome P 450 2 W 1 Converts − Colon Cancer
Purpose: Cytochrome P450 2W1 (CYP2W1) is a monooxygenase detected in 30% of colon cancers, whereas its expression in nontransformed adult tissues is absent, rendering it a tumor-specific drug targetExpand
Abstract 1779: CYP2W1 as a novel therapeutic target in colon cancer
TLDR
The findings reveal the opportunities in targeting CYP2W1 as a novel therapeutic approach in colon cancer chemotherapy and reveal that subtle changes in the duocarmycin pharmacophore can lead to dramatic changes (> 100-fold) in the anti-cancer activity. Expand
Some applications of optical fibers in medicine and disturbances in biomedical area
The development of medical equipment, telecommunications and computer's technology provides new possibilities for diagnostic purposes. Usually, it is necessary to use optical image or noiseExpand
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