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Gating Competence of Constitutively Open CLC-0 Mutants Revealed by the Interaction with a Small Organic Inhibitor
Opening of CLC chloride channels is coupled to the translocation of the permeant anion. From the recent structure determination of bacterial CLC proteins in the closed and open configuration, aExpand
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Proton Sensing of CLC-0 Mutant E166D
CLC Cl− channels are homodimers in which each subunit has a proper pore and a (fast) gate. An additional slow gate acts on both pores. A conserved glutamate (E166 in CLC-0) is a major determinant ofExpand
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Mechanisms of block of muscle type CLC chloride channels (Review)
CLC proteins are a nine-member gene family of Cl - channels that have diverse roles in the plasma membrane and in intracellular organelles. The recent structure determination of bacterial CLCExpand
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Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.
CLC channels are a gene family of Cl(-) channels that serve a variety of functions, several of which are involved in genetic diseases. Few specific ligands of CLC channels are known that could beExpand
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Structural requisites of 2‐(p‐chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC‐1
The 2‐(p‐chlorophenoxy)propionic acid (CPP) modulates in a stereoselective manner the macroscopic chloride conductance (gCl), the electrical parameter sustained by the CLC‐1 channel, of skeletalExpand
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Multiple pathways of Pb2+ permeation in rat cerebellar granule neurones
The pathways of lead (Pb2+) uptake were studied in fura‐2‐loaded cerebellar granule cells from 8‐day‐old rats. In a nominal Ca‐free external bath, Pb2+ (5–50 µm) determined an increase of theExpand
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Molecular modeling of p-chlorophenoxyacetic acid binding to the CLC-0 channel.
Molecular simulation techniques were applied to predict the interaction of the CLC-0 Cl(-) channel and the channel-blocking molecule p-chlorophenoxyacetic acid (CPA). A three-dimensional model of theExpand
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