• Publications
  • Influence
Calcium signalling--an overview.
Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. The ability ofExpand
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A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals.
Quantifying the magnitude of Ca2+ signals from changes in the emission of fluorescent indicators relies on assumptions about the indicator behaviour in situ. Factors such as osmolarity, pH, ionicExpand
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Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart
The roles of the Ca2+-mobilising messenger inositol 1,4,5-trisphosphate (InsP3) in heart are unclear, although many hormones activate InsP3 production in cardiomyocytes and some of their inotropic,Expand
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IP(3) receptors: toward understanding their activation.
  • C. Taylor, S. Tovey
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 1 December 2010
Inositol 1,4,5-trisphosphate receptors (IP(3)R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca(2+) release from intracellular stores. Their regulation by Ca(2+)Expand
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Ca2+ Entry Through Plasma Membrane IP3 Receptors
Inositol 1,4,5-trisphosphate receptors (IP3Rs) release calcium ions, Ca2+, from intracellular stores, but their roles in mediating Ca2+ entry are unclear. IP3 stimulated opening of very few (1.9 ±Expand
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Microscopic properties of elementary Ca2+ release sites in non-excitable cells
BACKGROUND Elementary Ca2+ signals, such as 'Ca2+ puffs', that arise from the activation of clusters of inositol 1 ,4,5,-trisphosphate (InsP3) receptors are the building blocks for local and globalExpand
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How does intracellular Ca2+ oscillate: by chance or by the clock?
Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standardExpand
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Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor
Inositol 1,4,5‐trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. Interactions of the commonly used antagonists of IP3Rs with IP3R subtypes are poorly understood.
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Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization of IP3Rs determines both the propagation of Ca2+ signals between IP3Rs and the selectiveExpand
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Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses.
Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca(2+) signalling. WeExpand
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