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- Publications
- Influence
Calcium signalling--an overview.
- M. Bootman, T. Collins, +9 authors P. Lipp
- Biology, Medicine
- Seminars in cell & developmental biology
- 1 February 2001
Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. The ability of… Expand
A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals.
- D. Thomas, S. Tovey, T. J. Collins, M. Bootman, M. Berridge, P. Lipp
- Biology, Medicine
- Cell calcium
- 1 October 2000
Quantifying the magnitude of Ca2+ signals from changes in the emission of fluorescent indicators relies on assumptions about the indicator behaviour in situ. Factors such as osmolarity, pH, ionic… Expand
Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart
- P. Lipp, M. Laine, +4 authors M. Bootman
- Biology, Medicine
- Current Biology
- 1 August 2000
The roles of the Ca2+-mobilising messenger inositol 1,4,5-trisphosphate (InsP3) in heart are unclear, although many hormones activate InsP3 production in cardiomyocytes and some of their inotropic,… Expand
IP(3) receptors: toward understanding their activation.
Inositol 1,4,5-trisphosphate receptors (IP(3)R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca(2+) release from intracellular stores. Their regulation by Ca(2+)… Expand
Ca2+ Entry Through Plasma Membrane IP3 Receptors
- O. Dellis, S. G. Dedos, S. Tovey, Taufiq-Ur-Rahman, S. Dubel, C. Taylor
- Chemistry, Medicine
- Science
- 14 July 2006
Inositol 1,4,5-trisphosphate receptors (IP3Rs) release calcium ions, Ca2+, from intracellular stores, but their roles in mediating Ca2+ entry are unclear. IP3 stimulated opening of very few (1.9 ±… Expand
Microscopic properties of elementary Ca2+ release sites in non-excitable cells
- D. Thomas, P. Lipp, +4 authors M. Bootman
- Biology, Medicine
- Current Biology
- 2000
BACKGROUND
Elementary Ca2+ signals, such as 'Ca2+ puffs', that arise from the activation of clusters of inositol 1 ,4,5,-trisphosphate (InsP3) receptors are the building blocks for local and global… Expand
How does intracellular Ca2+ oscillate: by chance or by the clock?
- Alexander Skupin, H. Kettenmann, +5 authors M. Falcke
- Biology, Medicine
- Biophysical journal
- 15 March 2008
Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard… Expand
Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor
- H. Saleem, S. Tovey, T. Molinski, C. Taylor
- Chemistry, Medicine
- British journal of pharmacology
- 10 June 2014
Inositol 1,4,5‐trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. Interactions of the commonly used antagonists of IP3Rs with IP3R subtypes are poorly understood.
Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
- Nagendra Babu Thillaiappan, Alap P. Chavda, S. Tovey, David L Prole, C. Taylor
- Chemistry, Medicine
- Nature Communications
- 15 November 2017
IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization of IP3Rs determines both the propagation of Ca2+ signals between IP3Rs and the selective… Expand
Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses.
- S. Tovey, P. De Smet, +9 authors M. Bootman
- Biology, Medicine
- Journal of cell science
- 15 November 2001
Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca(2+) signalling. We… Expand