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Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves.
AIM The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloidsExpand
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Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
Abstract Performance impairment during Δ9-tetrahydrocannabinol (THC) intoxication has been well described in occasional cannabis users. It is less clear whether tolerance develops to the impairingExpand
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Resistant hypertension? Assessment of adherence by toxicological urine analysis
Objective: Uncontrolled hypertension under antihypertensive multidrug regimen is not necessarily always true resistance. Incomplete adherence is one of several possible causes of uncontrolledExpand
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Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication
RationaleExperienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis.ObjectivesThe present study investigates whether event-related potentials (ERPs) differExpand
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Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms.
A study was performed to acquire urine, serum and oral fluid samples in cases of suspected driving under the influence of drugs of abuse. Oral fluid was collected using a novel sampling/testingExpand
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Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
IntroductionPrevious research has shown that heavy cannabis users develop tolerance to the impairing effects of Δ9-tetrahydrocannabinol (THC) on neurocognitive functions. Animal studies suggest thatExpand
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Excretion and detection of cathinone, cathine, and phenylpropanolamine in urine after kath chewing.
INTRODUCTION The stimulating herbal drug kath is uncommon in most countries, and information on its detection and interpretation of analytical results is limited. Therefore, a study with kath wasExpand
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Gas chromatographic-mass spectrometric detection of anhydroecgonine methyl ester (methylecgonidine) in human serum as evidence of recent smoking of crack.
The discrimination between smoking of crack and other routes of cocaine application has forensic implications. The pyrolysis product anhydroecgonine methyl ester (AEME, methylecgonidine) has beenExpand
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Pharmacokinetic properties of delta9-tetrahydrocannabinol in serum and oral fluid.
In a study on the effects of smoked cannabis (18.2 +/- 2.8 mg as low and 36.5 +/- 5.6 mg as high dose) paired blood and oral fluid samples were collected from 10 study participants up to 6 h afterExpand
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Pharmacokinetic properties of delta9-tetrahydrocannabinol in oral fluid of occasional and chronic users.
Saliva is of continuing interest in detecting the influence of drugs while driving. Commercial tests are currently available where cannabis detectability is a major challenge. The present study aidsExpand
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