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Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
The in vitro analysis of intestinal epithelium has been hampered by a lack of suitable culture systems. Here we describe robust long-term methodology for small and large intestinal culture,Expand
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Mast cells and angiogenesis
There is much evidence that angiogenesis is related to mast cells. Mast cells accumulate in many angiogenesis‐dependent situations, including tumor growth, rheumatoid arthritis, ovulation, wouldExpand
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Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.
BACKGROUND Subepithelial fibrosis is a cardinal feature of bronchial asthma. Collagen I, III, and V; fibronectin; and tenascin-C are deposited in the lamina reticularis. Extensive evidence supportsExpand
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Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The mechanismsExpand
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Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease: a pilot study
Background: Acoustic radiation force impulse (ARFI) is a new technology integrated into conventional B‐mode ultrasonography. ARFI is used to evaluate tissue stiffness in several organs, but thisExpand
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Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal form of interstitial lung disease (ILD). The precise molecular mechanisms of IPF remain poorly understood. However,Expand
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Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease1
Excessive production of airway mucus is a cardinal feature of bronchial asthma and chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality in these diseases. IL-13, aExpand
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Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions
Interaction between cancer and stromal cells is critical for tumour cell growth and invasion. It has recently been suggested that mature adipocytes, a specific type of stromal cell that is abundantExpand
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Prostate cancer cell growth is modulated by adipocyte‐cancer cell interaction
To assess whether adipocytes (mesenchymal stromal cells thought to affect the proliferation and differentiation of epithelial cells) affect the behaviour of prostate cancer cells in vitro, asExpand
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T Cell Deficiency Leads to Liver Carcinogenesis in Azoxymethane-Treated Rats
There is an increasing amount of evidence suggesting that T cell deficiency contributes to tumor development. However, it is unclear whether T cell deficiency leads to liver and colon carcinogenesis.Expand
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