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- Publications
- Influence
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
- Akifumi Ootani, X. Li, +8 authors C. Kuo
- Biology, Medicine
- Nature Medicine
- 1 June 2009
The in vitro analysis of intestinal epithelium has been hampered by a lack of suitable culture systems. Here we describe robust long-term methodology for small and large intestinal culture,… Expand
Mast cells and angiogenesis
- Y. Hiromatsu, S. Toda
- Biology, Medicine
- Microscopy research and technique
- 2003
There is much evidence that angiogenesis is related to mast cells. Mast cells accumulate in many angiogenesis‐dependent situations, including tumor growth, rheumatoid arthritis, ovulation, would… Expand
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.
- G. Takayama, K. Arima, +7 authors K. Izuhara
- Medicine
- The Journal of allergy and clinical immunology
- 1 July 2006
BACKGROUND
Subepithelial fibrosis is a cardinal feature of bronchial asthma. Collagen I, III, and V; fibronectin; and tenascin-C are deposited in the lamina reticularis. Extensive evidence supports… Expand
Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
- M. Masuoka, H. Shiraishi, +15 authors K. Izuhara
- Biology, Medicine
- The Journal of clinical investigation
- 2 July 2012
Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The mechanisms… Expand
Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease: a pilot study
- H. Takahashi, N. Ono, +11 authors K. Fujimoto
- Medicine
- Liver international : official journal of the…
- 1 April 2010
Background: Acoustic radiation force impulse (ARFI) is a new technology integrated into conventional B‐mode ultrasonography. ARFI is used to evaluate tissue stiffness in several organs, but this… Expand
Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis.
- M. Uchida, H. Shiraishi, +14 authors K. Izuhara
- Biology, Medicine
- American journal of respiratory cell and…
- 1 May 2012
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal form of interstitial lung disease (ILD). The precise molecular mechanisms of IPF remain poorly understood. However,… Expand
Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease1
- Isao Nakao, S. Kanaji, +24 authors K. Izuhara
- Medicine
- The Journal of Immunology
- 1 May 2008
Excessive production of airway mucus is a cardinal feature of bronchial asthma and chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality in these diseases. IL-13, a… Expand
Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions
- Yasushi Manabe, S. Toda, K. Miyazaki, H. Sugihara
- Biology, Medicine
- The Journal of pathology
- 1 October 2003
Interaction between cancer and stromal cells is critical for tumour cell growth and invasion. It has recently been suggested that mature adipocytes, a specific type of stromal cell that is abundant… Expand
Prostate cancer cell growth is modulated by adipocyte‐cancer cell interaction
- Y. Tokuda, Y. Satoh, C. Fujiyama, S. Toda, H. Sugihara, Z. Masaki
- Medicine
- BJU international
- 1 May 2003
To assess whether adipocytes (mesenchymal stromal cells thought to affect the proliferation and differentiation of epithelial cells) affect the behaviour of prostate cancer cells in vitro, as… Expand
T Cell Deficiency Leads to Liver Carcinogenesis in Azoxymethane-Treated Rats
- B. Wu, A. Ootani, +7 authors K. Fujimoto
- Biology, Medicine
- Experimental biology and medicine
- 1 January 2006
There is an increasing amount of evidence suggesting that T cell deficiency contributes to tumor development. However, it is unclear whether T cell deficiency leads to liver and colon carcinogenesis.… Expand